caa a22 4500 445373016 CHVBK 20180317142953.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00540-010-1042-y doi (NATIONALLICENCE)springer-10.1007/s00540-010-1042-y Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery [Elektronische Daten] [Judith Hudetz, Sweeta Gandhi, Zafar Iqbal, Kathleen Patterson, Paul Pagel] Purpose: We tested the hypothesis that elevated postoperative interleukin-6 (IL-6) and C-reactive protein (CRP) concentrations are associated with short- and medium-term impairment of cognitive functions in patients after coronary artery surgery using cardiopulmonary bypass. Methods: Eighty-six age- and education-balanced patients ≥55years of age undergoing elective coronary artery bypass surgery with cardiopulmonary bypass and 28 nonsurgical controls with coronary artery disease were enrolled. Recent verbal and nonverbal memory and executive functions were assessed before surgery and at 1week and 3months after surgery using a cognitive test battery. IL-6 concentrations were measured before surgery and 4h after cardiopulmonary bypass, and CRP concentrations were measured before surgery and at 24 and 72h after anesthetic induction. Overall cognitive function between high and low biomarker concentration groups was analyzed by the Wilcoxon rank-sum test. Results: Recent memory was at least 1 standard deviation (SD) impaired at 1week and 3months in the high-CRP compared with low-CRP and in the high-IL-6 compared with low-IL-6 concentration groups. Overall cognitive function was significantly (P=0.04 and P=0.01, respectively) different between the high- and low-CRP concentration groups (CRP assayed 24 h after anesthetic induction) at both 1week and 3months. Overall cognitive function was also significantly (P=0.04) different between the high- and low-IL-6 concentration groups at 1week after surgery. Conclusion: The results suggest that elevated postoperative IL-6 and CRP concentrations are associated with the subsequent development of short- and medium-term impairment of cognitive functions after coronary artery surgery. Japanese Society of Anesthesiologists, 2010 C-reactive protein nationallicence Interleukin-6 nationallicence Coronary artery bypass graft nationallicence Cardiopulmonary bypass nationallicence Postoperative cognitive dysfunction nationallicence Hudetz Judith Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut Gandhi Sweeta Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut Iqbal Zafar Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut Patterson Kathleen Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut Pagel Paul Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut Journal of Anesthesia Springer Japan 25/1(2011-02-01), 1-9 0913-8668 25:1<1 2011 25 540 https://doi.org/10.1007/s00540-010-1042-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-010-1042-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hudetz Judith Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Gandhi Sweeta Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Iqbal Zafar Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Patterson Kathleen Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Pagel Paul Department of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000 W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/1(2011-02-01), 1-9 0913-8668 25:1<1 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer