caa a22 4500 445373091 CHVBK 20180317142953.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00540-010-1049-4 doi (NATIONALLICENCE)springer-10.1007/s00540-010-1049-4 Effect of divided supplementation of remifentanil on seizure duration and hemodynamic responses during electroconvulsive therapy under propofol anesthesia [Elektronische Daten] [Kohki Nishikawa, Misako Higuchi, Toshiya Kawagishi, Yuki Shimodate, Michiaki Yamakage] Purpose: Although a reduced dose of propofol combined with remifentanil is often used in anesthesia for electroconvulsive therapy (ECT), there have been few studies in which the optimal technique for injection of remifentanil was examined in detail. The aim of this study was to evaluate the effects of single and divided injection of remifentanil combined with propofol on seizure duration and hemodynamic responses during ECT. Methods: Twenty-six ASA I-II patients were enrolled in this study and received a total of 78 ECTs. Each patient received propofol 1.2mg/kg (group P), remifentanil 1μg/kg followed by propofol 0.5mg/kg (group R1), and remifentanil 1μg/kg followed by propofol 0.5mg/kg and thereafter remifentanil 2μg/kg (group R2). Succinylcholine 1mg/kg was used for muscle paralysis after loss of consciousness. Results: Although mean motor seizure durations were significantly longer in groups R1 and R2 than in group P (P<0.05), they were similar in groups R1 and R2. Although the percentage increases in mean arterial pressure after ECT were significantly smaller in groups P (P<0.01) and R2 (P<0.05) than in group R1, they did not significantly differ between groups P and R2. Conclusions: Divided use of remifentanil at 1 and 2μg/kg combined with propofol 0.5mg/kg produces an acceptable outcome in both seizure duration and hemodynamic stability during ECT compared with the standard hypnotic doses of propofol alone or remifentanil 1μg/kg followed by propofol 0.5mg/kg. Japanese Society of Anesthesiologists, 2010 Propofol nationallicence Remifentanil nationallicence Electroconvulsive therapy nationallicence Seizure duration nationallicence Hemodynamic response nationallicence Nishikawa Kohki Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut Higuchi Misako Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut Kawagishi Toshiya Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut Shimodate Yuki Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut Yamakage Michiaki Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan aut Journal of Anesthesia Springer Japan 25/1(2011-02-01), 29-33 0913-8668 25:1<29 2011 25 540 https://doi.org/10.1007/s00540-010-1049-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-010-1049-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishikawa Kohki Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut NATIONALLICENCE 700 1- Higuchi Misako Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut NATIONALLICENCE 700 1- Kawagishi Toshiya Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut NATIONALLICENCE 700 1- Shimodate Yuki Department of Anesthesia, Muroran City General Hospital, 3-8-1 Yamate-chou, 051-8512, Muroran, Hokkaido, Japan aut NATIONALLICENCE 700 1- Yamakage Michiaki Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/1(2011-02-01), 29-33 0913-8668 25:1<29 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer