caa a22 4500 445373105 CHVBK 20180317142953.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1216-2 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1216-2 Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats [Elektronische Daten] [Takashi Kawano, Tomohiro Soga, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki, Naoko Kumagai, Masataka Yokoyama] The neurosteroid allopregnanolone (AP) influences the excitability of the central nervous system by acting as a positive allosteric modulator of γ-aminobutyric acid type A (GABAA) receptors. Here, we investigated the role of AP and its therapeutic potential in rats that showed hyperalgesic behavior after undergoing spinal nerve ligation (SNL). AP levels measured in the spinal cord and brain of rats that underwent SNL were greater than the corresponding levels in control animals. More importantly, spinal AP levels in hyperalgesic rats were lower than those in the rats that did not develop hyperalgesia following SNL; in contrast, brain AP levels were comparable among these groups. No differences in serum AP levels were observed among the groups. In addition, intrathecal exogenous administration of AP showed the antihyperalgesic effects in hyperalgesic rats after SNL. These findings suggest that changes in spinal AP biosynthesis are involved in the pathogenesis of neuropathic pain following peripheral nerve injury, and pharmacological manipulation of this phenomenon may provide a potential therapeutic target for neuropathic pain. Japanese Society of Anesthesiologists, 2011 Neurosteroid nationallicence Neuropathic pain nationallicence Hyperalgesia nationallicence Kawano Takashi Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan aut Soga Tomohiro Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan aut Chi Haidong Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan aut Eguchi Satoru Department of Dental Anesthesiology, Tokushima University School of Dentistry, Tokushima, Japan aut Yamazaki Fumimoto Department of Anesthesiology, Tosa Citizen Hospital, Tosa, Kochi, Japan aut Kumagai Naoko Clinical Trial Center, Kochi Medical School, Kochi, Japan aut Yokoyama Masataka Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 942-945 0913-8668 25:6<942 2011 25 540 https://doi.org/10.1007/s00540-011-1216-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1216-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawano Takashi Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan aut NATIONALLICENCE 700 1- Soga Tomohiro Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan aut NATIONALLICENCE 700 1- Chi Haidong Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan aut NATIONALLICENCE 700 1- Eguchi Satoru Department of Dental Anesthesiology, Tokushima University School of Dentistry, Tokushima, Japan aut NATIONALLICENCE 700 1- Yamazaki Fumimoto Department of Anesthesiology, Tosa Citizen Hospital, Tosa, Kochi, Japan aut NATIONALLICENCE 700 1- Kumagai Naoko Clinical Trial Center, Kochi Medical School, Kochi, Japan aut NATIONALLICENCE 700 1- Yokoyama Masataka Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 942-945 0913-8668 25:6<942 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer