caa a22 4500 445373121 CHVBK 20180317142953.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1224-2 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1224-2 Pentazocine increases bispectral index without surgical stimulation during nitrous oxide-sevoflurane anesthesia [Elektronische Daten] [Kazuyuki Onuki, Noriko Onuki, Toshikatsu Imamura, Yuichiro Yamanishi, Shumei Yoshikawa, Satoshi Hagihira, Jun Shimada, Hiroshi Nagasaka] Although there have been a large number of reports on the effects of opioids on the bispectral index (BIS) during anesthesia, the effects of pentazocine on the BIS have not been reported. In this study, 60 patients scheduled for elective oral surgery [30 females, 30 males; all American Society of Anesthesiologists Physical Status (ASA PS) category 1] were enrolled in the trials. Maintaining gender parity, we randomly assigned the patients to one of three groups: pentazocine group (0.3mg/kg; n=20), fentanyl group (1μg/kg; n=20), or saline group (n=20); these opioids were administered intravenously 15min after the intubation. Anesthesia was induced with thiopental and vecuronium bromide and maintained with nitrous oxide (4l/min)-oxygen (2l/min)-sevoflurane (1%). At 15 min after the intubation, mean arterial blood pressure (MAP), heart rate (HR), and BIS index were recorded as baseline values. MAP, HR, and BIS values were measured at 2.5-min after the intubation up to 30min. All data were expressed as the mean±standard deviation. Differences in BIS values, MAP, and HR among the three groups throughout the experiment were analyzed using two-way repeated-measures analysis of variance (ANOVA), and demographic data among the three groups were analyzed using one-way ANOVA. Post hoc comparisons were performed using Fisher's protected least significant difference test. A P value of <0.05 was considered to indicate statistically significance. MAP and HR showed no significant differences among the three groups during the study. BIS values significantly increased between 5 and 15min after the intubation relative to the baseline value in the pentazocine group (P<0.001), and BIS values in this group were significantly during this time period than those in the fentanyl and saline group (P<0.001). BIS values were not significantly different between the fentanyl group and saline group. These results indicated that pentazocine, but not fentanyl, under nitrous oxide-sevoflurane anesthesia caused a statistically significant increase in BIS in our patients. Japanese Society of Anesthesiologists, 2011 Pentazocine nationallicence Fentanyl nationallicence Bispectral index nationallicence Onuki Kazuyuki Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut Onuki Noriko Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut Imamura Toshikatsu Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut Yamanishi Yuichiro Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut Yoshikawa Shumei Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Japan aut Hagihira Satoshi Department of Anesthesiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan aut Shimada Jun Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Japan aut Nagasaka Hiroshi Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 946-949 0913-8668 25:6<946 2011 25 540 https://doi.org/10.1007/s00540-011-1224-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1224-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Onuki Kazuyuki Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut NATIONALLICENCE 700 1- Onuki Noriko Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut NATIONALLICENCE 700 1- Imamura Toshikatsu Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut NATIONALLICENCE 700 1- Yamanishi Yuichiro Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut NATIONALLICENCE 700 1- Yoshikawa Shumei Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Japan aut NATIONALLICENCE 700 1- Hagihira Satoshi Department of Anesthesiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Shimada Jun Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Japan aut NATIONALLICENCE 700 1- Nagasaka Hiroshi Division of Anesthesiology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 350-0283, Sakado, Saitama, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 946-949 0913-8668 25:6<946 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer