caa a22 4500 445373156 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1236-y doi (NATIONALLICENCE)springer-10.1007/s00540-011-1236-y Comparison of recovery times from rocuronium-induced muscle relaxation after reversal with three different doses of sugammadex and succinylcholine during electroconvulsive therapy [Elektronische Daten] [Yuji Kadoi, Hiroko Hoshi, Akiko Nishida, Shigeru Saito] Purpose: This study was conducted to compare recovery times from rocuronium-induced muscle relaxation after reversal with three different doses of sugammadex with succinylcholine during electroconvulsive therapy (ECT). Methods: Seventeen patients who were scheduled to undergo ECT were studied. Anesthesia was induced by use of propofol (1.0mg/kg) followed by either succinylcholine (SCC) (1mg/kg) or rocuronium (0.6mg/kg). Assisted mask ventilation was initiated with 100% oxygen. After T1 was assessed as being zero by neuromuscular monitoring, an electroshock stimulus was applied bilaterally. Patients receiving rocuronium were infused with 16, 8, or 4mg/kg sugammadex immediately after the seizure stopped to reverse the muscle relaxation. Neuromuscular monitoring was continued until recovery of the train-of-four ratio to 0.9 at the tibial nerve in the leg. The times to recovery of T1 to 10 and 90% with both relaxants were compared. Results: The time to recovery of T1 to 90% after 16mg/kg sugammadex was shorter than that in subjects treated with SCC (p=0.046), whereas that after 4mg/kg sugammadex was longer than that in subjects treated with SCC (SCC group: 429±65s, 16mg/kg sugammadex group: 387±63s*, 8mg/kg sugammadex group: 462±66s, 4mg/kg sugammadex group: 563±45s*,#; *p<0.05 compared with SCC, # p<0.01 compared with 16mg/kg sugammadex). Conclusions: This study demonstrates the efficacy of rocuronium-sugammadex as an alternative to SCC for muscle relaxation during ECT, and indicates that 8mg/kg sugammadex produces equally rapid recovery from rocuronium muscular relaxation compared with spontaneous recovery from 1mg/kg SCC during ECT. Japanese Society of Anesthesiologists, 2011 Electroconvulsive therapy nationallicence Muscle relaxant nationallicence Rocuronium nationallicence Sugammadex nationallicence Succinylcholine nationallicence Kadoi Yuji Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut Hoshi Hiroko Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut Nishida Akiko Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut Saito Shigeru Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 855-859 0913-8668 25:6<855 2011 25 540 https://doi.org/10.1007/s00540-011-1236-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1236-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kadoi Yuji Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Hoshi Hiroko Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Nishida Akiko Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Saito Shigeru Department of Anesthesiology, Gunma University, School of Medicine, 3-39-22 Showa-Machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 855-859 0913-8668 25:6<855 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer