caa a22 4500 445373172 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1212-6 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1212-6 Sevoflurane to alleviate pain on propofol injection [Elektronische Daten] [Kalindi DeSousa, Mohamed Ali] Purpose: Since the introduction of propofol, several drugs and methods have been used to alleviate the pain on its injection. This study was designed to evaluate the effect of adding sevoflurane 3% during preoxygenation in alleviation of pain on propofol injection. Methods: In this randomized single-blinded study, 100 patients were randomly allocated equally into five groups: sevoflurane-lidocaine-tourniquet (SLT), sevoflurane-lidocaine (SL), lidocaine-tourniquet (LT), lidocaine (L), and sevoflurane (S). Approximately 10min before the induction of anesthesia, midazolam 1-2mg was administered intravenously to all patients. All patients received fentanyl 1µg/kg as pretreatment and a full induction dose of propofol. A blinded anesthesia nurse assessed pain and hand movements throughout the injection of propofol. Results: In the SLT group, all patients (100%) were pain free and had no hand movements. There was no significant difference in pain grade or in hand movements between the L and the S groups, or between the SLT and the SL groups. However, significant differences were observed in pain grade between the SLT and the L groups as well as between the SLT and the S groups. In addition, a significant difference in hand movement was observed only between the SLT and the S groups. Conclusion: The addition of 3% sevoflurane at the time of preoxygenation for 1min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol. Japanese Society of Anesthesiologists, 2011 Propofol nationallicence Pain nationallicence Sevoflurane nationallicence Lidocaine nationallicence DeSousa Kalindi Department of Anaesthesia and ICU, Al Salam International Hospital, 35151, Kuwait, Kuwait aut Ali Mohamed Department of Anaesthesia and ICU, Al Salam International Hospital, 35151, Kuwait, Kuwait aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 879-883 0913-8668 25:6<879 2011 25 540 https://doi.org/10.1007/s00540-011-1212-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1212-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DeSousa Kalindi Department of Anaesthesia and ICU, Al Salam International Hospital, 35151, Kuwait, Kuwait aut NATIONALLICENCE 700 1- Ali Mohamed Department of Anaesthesia and ICU, Al Salam International Hospital, 35151, Kuwait, Kuwait aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 879-883 0913-8668 25:6<879 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer