caa a22 4500 445373229 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1230-4 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1230-4 Amino acid infusions started after development of intraoperative core hypothermia do not affect rewarming but reduce the incidence of postoperative shivering during major abdominal surgery: a randomized trial [Elektronische Daten] [Satoki Inoue, Takeaki Shinjo, Masahiko Kawaguchi, Yoshiyuki Nakajima, Hitoshi Furuya] Purpose: Previous studies have demonstrated that amino acid infusions exert enhanced thermogenic effects during general anesthesia. This study was conducted to investigate whether amino acid infusions started after development of intraoperative core hypothermia can accelerate rewarming. Methods: Twenty-two patients scheduled for major abdominal surgery were included in this study. When tympanic temperature reached 35.5°C, patients were randomly assigned to receive amino acids (amino acid group; n=11) or saline (saline group; n=11). A continuous infusion of a mixture of 18 amino acids or saline was started at 200mlh−1. Tympanic, forearm, and digit temperatures were recorded. Forearm minus fingertip skin-surface temperature gradients (temperature gradient) were calculated. Postoperative shivering was also evaluated. Results: Tympanic membrane temperature and temperature gradient were similar between the two groups at each time point during the study period. Temperature gradient at extubation in the amino acid group was significantly lower than in the saline group although tympanic temperature at extubation was similar between the two groups. Postoperative shivering score was significantly lower in the amino acid group than in the saline group. Conclusions: Amino acid infusions started after development of intraoperative core hypothermia failed to accelerate rewarming. However, amino acid infusions reduced the incidence of postoperative shivering. Use of amino acid infusions to reduce thermoregulatory vasoconstriction at emergence might contribute to a decrease in the development of postoperative shivering. Japanese Society of Anesthesiologists, 2011 Amino acid nationallicence Hypothermia nationallicence Shivering nationallicence Inoue Satoki Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Shinjo Takeaki Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Kawaguchi Masahiko Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Nakajima Yoshiyuki Department of Surgery, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Furuya Hitoshi Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 850-854 0913-8668 25:6<850 2011 25 540 https://doi.org/10.1007/s00540-011-1230-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1230-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue Satoki Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Shinjo Takeaki Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Kawaguchi Masahiko Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Nakajima Yoshiyuki Department of Surgery, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Furuya Hitoshi Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 850-854 0913-8668 25:6<850 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer