caa a22 4500 445373245 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1239-8 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1239-8 Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements: a randomized control trial [Elektronische Daten] [Norimasa Ohtani, Yutaka Yasui, Daisuke Watanabe, Mari Kitamura, Kazuhiro Shoji, Eiji Masaki] Purpose: We hypothesized that a high dose of dexmedetomidine (1μg/kg/h) could reduce postoperative analgesic requirements of patients. Methods: This was a prospective, randomized, double-blind, placebo-controlled study carried out in Tohoku University Hospital. Thirty-two patients who underwent open gynecological abdominal surgery were randomly divided into a control (group C) and a dexmedetomidine group (group D). In both groups of patients, an epidural catheter was put in position prior to the induction of anesthesia, and continuous epidural infusion was started using a patient-controlled epidural analgesia (PCEA) pump. During the induction of anesthesia, group D patients received a loading dose of dexmedetomidine (1μg/kg over 10min), followed by a continuous infusion at a rate of 1μg/kg/h. The patients in group C received a volume-matched infusion of normal saline as placebo. Consumption of PCEA bolus (local anesthetics) during the first postoperative 24h, postoperative pain scores, and side effects related to the use of dexmedetomidine were recorded. Results: Dexmedetomidine (1μg/kg/h) significantly reduced PCEA bolus consumption [15.9±6.5 (group C) vs. 5.3±5.0ml (group D); P=0.0001] and postoperative pain scores. The infusion of dexmedetomidine produced no serious side effects, such as hemodynamic changes. Conclusions: Among this small patient cohort, perioperative infusion of dexmedetomidine (1μg/kg/h) resulted in antinociception without severe side effects. These results suggest that this method could be of interest with respect to improving postoperative pain status. Japanese Society of Anesthesiologists, 2011 Dexmedetomidine nationallicence Postoperative pain nationallicence Patient-controlled analgesia nationallicence Ohtani Norimasa Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, 980-8575, Aoba-ku, Sendai, Japan aut Yasui Yutaka Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan aut Watanabe Daisuke Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, 980-8575, Aoba-ku, Sendai, Japan aut Kitamura Mari Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan aut Shoji Kazuhiro Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan aut Masaki Eiji Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, 980-8575, Aoba-ku, Sendai, Japan aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 872-878 0913-8668 25:6<872 2011 25 540 https://doi.org/10.1007/s00540-011-1239-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1239-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohtani Norimasa Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, 980-8575, Aoba-ku, Sendai, Japan aut NATIONALLICENCE 700 1- Yasui Yutaka Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Watanabe Daisuke Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, 980-8575, Aoba-ku, Sendai, Japan aut NATIONALLICENCE 700 1- Kitamura Mari Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Shoji Kazuhiro Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Masaki Eiji Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, 980-8575, Aoba-ku, Sendai, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 872-878 0913-8668 25:6<872 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer