caa a22 4500 445373326 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1227-z doi (NATIONALLICENCE)springer-10.1007/s00540-011-1227-z Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: a randomized, double-blind trial in patients undergoing lower extremity surgery [Elektronische Daten] [Gholamreza Khalili, Mohsen Janghorbani, Parvin Sajedi, Gholamhossein Ahmadi] Purpose: The aim of this study was to evaluate the effect of additional magnesium sulfate (MgSO4) 100mg to intrathecal (IT) isobaric 0.5% bupivacaine 3ml on spinal anesthesia in patients undergoing lower extremity orthopedic surgery. Methods: In a double-blind randomized clinical trial, 79 American Association of Anesthesiologists (ASA) I or II adult patients undergoing lower extremity orthopedic surgery were recruited. The patients were randomly allocated to receive 100mg MgSO4 5% (0.2ml) plus 15mg of bupivacaine 0.5% (MgSO4 group) or 15mg bupivacaine 0.5% combined with 0.2ml normal saline (control group) intrathecally. Response to treatment was assessed as onset and duration of sensory block, the highest level of sensory block, time to complete motor block recovery, duration of spinal anesthesia, and postoperative analgesic requirement. Results: The onset of the sensory block was slower in the MgSO4 group than in the control group (13.3 vs. 11.6min, P=0.04), and the duration of the sensory blockade was significantly longer in the MgSO4 group than the control group (106.5 vs. 85.5min, P=0.001). Total analgesic requirements for 24h following surgery were lower in the MgSO4 group than in the control group (96.8 vs. 138.5mg, P=0.001). Mean duration of spinal anesthesia was not significantly different between two groups (178.0 vs. 167.4min, P=0.23). Conclusion: In patients undergoing lower extremity surgery with spinal anesthesia, the addition of 100mg IT MgSO4 to 15mg bupivacaine without opioid supplement, prolonged the duration of the sensory block, decreased postoperative analgesic consumption, and significantly prolonged the onset of spinal anesthesia. Japanese Society of Anesthesiologists, 2011 Bupivacaine nationallicence Drugs nationallicence Efficacy nationallicence Intrathecal nationallicence Magnesium sulfate nationallicence Spinal anesthesia nationallicence Khalili Gholamreza Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut Janghorbani Mohsen Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut Sajedi Parvin Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut Ahmadi Gholamhossein Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 892-897 0913-8668 25:6<892 2011 25 540 https://doi.org/10.1007/s00540-011-1227-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1227-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khalili Gholamreza Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut NATIONALLICENCE 700 1- Janghorbani Mohsen Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut NATIONALLICENCE 700 1- Sajedi Parvin Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut NATIONALLICENCE 700 1- Ahmadi Gholamhossein Anesthesiology and Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 892-897 0913-8668 25:6<892 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer