caa a22 4500 445373369 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00540-011-1237-x doi (NATIONALLICENCE)springer-10.1007/s00540-011-1237-x Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial [Elektronische Daten] [Zhen-Tao Sun, Chun-Yao Yang, Zhi Cui, Jie Zhang, Xue-Ping Han] Purpose: To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia. Methods: A total of 120 patients, American Society of Anesthesiologists (ASA) physical status I-II, were randomized into two equally sized groups (n = 60). These two groups were given either intravenous dezocine 0.1mg/kg or a matching placebo (equal volume of 0.9% saline) 10min before the induction of general anesthesia. Patients were induced with midazolam 0.1mg/kg, fentanyl 5μg/kg, propofol 1-1.5mg/kg, and suxamethonium 1.5mg/kg. The injection time of fentanyl was less than 2s in all patients. The occurrence of cough was recorded 2min after fentanyl bolus. Results: No patient in the dezocine group had cough, and 42 patients in the control group had cough. This difference was statistically different between these two groups (P=0.000). Conclusion: These results demonstrate that intravenous dezocine 0.1mg/kg 10min prior to induction was effective in suppressing fentanyl-induced cough in our patients. Japanese Society of Anesthesiologists, 2011 Fentanyl nationallicence Cough nationallicence Dezocine nationallicence General anesthesia nationallicence Suppress nationallicence Sun Zhen-Tao Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut Yang Chun-Yao Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut Cui Zhi Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut Zhang Jie Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut Han Xue-Ping Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut Journal of Anesthesia Springer Japan 25/6(2011-12-01), 860-863 0913-8668 25:6<860 2011 25 540 https://doi.org/10.1007/s00540-011-1237-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1237-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Zhen-Tao Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut NATIONALLICENCE 700 1- Yang Chun-Yao Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut NATIONALLICENCE 700 1- Cui Zhi Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut NATIONALLICENCE 700 1- Zhang Jie Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut NATIONALLICENCE 700 1- Han Xue-Ping Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/6(2011-12-01), 860-863 0913-8668 25:6<860 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer