caa a22 4500 445373407 CHVBK 20180317142954.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00540-011-1109-4 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1109-4 Possible augmentation of neuromuscular blockade by propofol during recovery from rocuronium [Elektronische Daten] [Heiner Ruschulte, Theresa Ward, Ronald Miller, Matthias Braehler] Propofol is a widely used drug in anesthesia practice, and its pharmacological characteristics are well known. However, propofol is not known for neuromuscular effects. As part of clinical neuromuscular monitoring, the neuromuscular responses to train-of-four (TOF) stimulation were monitored and recorded. We observed, in two cases of balanced anesthesia maintained by desflurane and fentanyl, that administration of a small dose of propofol during almost complete recovery from rocuronium in two patients resulted in marked decreases of both T1 (first twitch response of the TOF) and the TOF ratio. This neuromuscular block dissipated in both patients without any subsequent neuromuscular effects. These two observations provide visual confirmation of the possible impact of propofol on recovery from a rocuronium neuromuscular blockade. Japanese Society of Anesthesiologists, 2011 Neuromuscular blockade nationallicence Rocuronium nationallicence Propofol nationallicence Drug interaction nationallicence Train-of-four nationallicence Ruschulte Heiner Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut Ward Theresa Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut Miller Ronald Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut Braehler Matthias Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut Journal of Anesthesia Springer Japan 25/3(2011-06-01), 438-441 0913-8668 25:3<438 2011 25 540 https://doi.org/10.1007/s00540-011-1109-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1109-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ruschulte Heiner Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Ward Theresa Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Miller Ronald Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Braehler Matthias Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Avenue, Box 0648, 94143, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/3(2011-06-01), 438-441 0913-8668 25:3<438 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer