caa a22 4500 44537344X CHVBK 20180317142955.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00540-011-1137-0 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1137-0 Postoperative cognitive dysfunction after noncardiac surgery: effects of metabolic syndrome [Elektronische Daten] [Judith Hudetz, Kathleen Patterson, Oludara Amole, Aaron Riley, Paul Pagel] Purpose: Vascular risk factors, including metabolic syndrome, are known to contribute to the development of cognitive dysfunction. We tested the hypothesis that patients with metabolic syndrome are more likely to develop cognitive dysfunction after noncardiac surgery. Methods: Age- and education-balanced patients (n=60) undergoing elective noncardiac surgery with and without metabolic syndrome and 30 nonsurgical controls were enrolled. Recent verbal and nonverbal memory and executive functions were assessed using a psychometric test battery before and 1month after noncardiac surgery or at a 1-month interval in nonsurgical controls. Results: Neurocognitive scores under baseline conditions were similar in surgical patients with versus without metabolic syndrome in all examined cognitive modalities (recent nonverbal and verbal memory, executive functions). Pronounced reductions in tests of verbal memory (delayed story recall, immediate and delayed word list recall) and executive function (backward digit span) were observed in patients with versus without metabolic syndrome after surgery. Overall cognitive performance after surgery was also significantly (P=0.03) more impaired in patients with versus without metabolic syndrome. The prevalence rate of postoperative cognitive dysfunction (POCD) differed in the studied groups (13/30 and 8/30 in patients with versus without metabolic syndrome; P<0.02). Conclusions: The results indicate that cognitive functions were more profoundly impaired in patients with metabolic syndrome undergoing noncardiac surgery compared with their healthier counterparts. Japanese Society of Anesthesiologists, 2011 Metabolic syndrome nationallicence Postoperative cognitive dysfunction nationallicence Hudetz Judith Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut Patterson Kathleen Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA aut Amole Oludara Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut Riley Aaron Division of Psychiatry, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut Pagel Paul Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut Journal of Anesthesia Springer Japan 25/3(2011-06-01), 337-344 0913-8668 25:3<337 2011 25 540 https://doi.org/10.1007/s00540-011-1137-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1137-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hudetz Judith Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Patterson Kathleen Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Amole Oludara Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Riley Aaron Division of Psychiatry, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Pagel Paul Division of Anesthesiology, Clement J. Zablocki Veterans Administration Medical Center, 5000W. National Avenue, 53295, Milwaukee, WI, USA aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/3(2011-06-01), 337-344 0913-8668 25:3<337 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer