caa a22 4500 445373512 CHVBK 20180317142955.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00540-011-1119-2 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1119-2 Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents [Elektronische Daten] [Maria Metaxari, Alexandra Papaioannou, Anastasios Petrou, Aikaterini Chatzimichali, Elena Pharmakalidou, Helen Askitopoulou] Purpose: The aim of this double-blind randomized study was to compare the antiemetic efficacy of three 5-hydroxytryptamine type 3 antagonists in terms of the incidence and intensity of postoperative nausea and vomiting (PONV) in a homogenous group of female patients undergoing thyroidectomy. Methods: The study cohort consisted of 203 American Society of Anesthesiologists PS I-II female patients randomized into four groups to receive at induction of anesthesia an intravenous (IV) bolus of 5ml solution of one of the following: normal saline (placebo), granisetron 3mg, ondansetron 4mg, or tropisetron 5mg. Nausea and vomiting were evaluated at five time points: during the first hour in the postanesthesia care unit (PACU) and 6, 12, 18, and 24h postoperatively. Nausea intensity was measured using a visual analogue scale score (0-10). Results: Patients in the placebo group displayed a high incidence of nausea in the PACU and at 6, 12, and 18h postoperatively (44, 60, 50, and 34%, respectively) and of vomiting (26, 42, 30 and 10%). The administration of granisetron reduced significantly the incidence of nausea at 6, 12, and 18h (26, 18, and 2%, respectively) and vomiting at 6 and 12h (10 and 6%, respectively). Ondansetron reduced significantly the incidence of nausea and vomiting only at 6h postoperatively (28 and 12%, respectively). The administration of tropisetron did not affect the incidence of PONV compared to placebo. Conclusion: Among the female patients of this study undergoing thyroid surgery, granisetron 3mg provided the best prophylaxis from PONV. Ondansetron 4mg was equally effective, but its action lasted only 6h, whereas tropisetron 5mg was found ineffective. Japanese Society of Anesthesiologists, 2011 PONV nationallicence Granisetron nationallicence Ondansetron nationallicence Tropisetron nationallicence Thyroid surgery nationallicence Metaxari Maria Department of Anesthesiology, University Hospital of Heraklion, Heraklion, Crete, Greece aut Papaioannou Alexandra Medical School, University of Crete, P.O. Box 2208, 71003, Heraklion, Crete, Greece aut Petrou Anastasios Department of Anesthesiology, University Hospital of Ioannina, Ioannina, Greece aut Chatzimichali Aikaterini Department of Anesthesiology, University Hospital of Heraklion, Heraklion, Crete, Greece aut Pharmakalidou Elena Department of Anesthesiology, General Hospital of Paphos, Paphos, Cyprus aut Askitopoulou Helen Medical School, University of Crete, P.O. Box 2208, 71003, Heraklion, Crete, Greece aut Journal of Anesthesia Springer Japan 25/3(2011-06-01), 356-362 0913-8668 25:3<356 2011 25 540 https://doi.org/10.1007/s00540-011-1119-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1119-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Metaxari Maria Department of Anesthesiology, University Hospital of Heraklion, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Papaioannou Alexandra Medical School, University of Crete, P.O. Box 2208, 71003, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Petrou Anastasios Department of Anesthesiology, University Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Chatzimichali Aikaterini Department of Anesthesiology, University Hospital of Heraklion, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Pharmakalidou Elena Department of Anesthesiology, General Hospital of Paphos, Paphos, Cyprus aut NATIONALLICENCE 700 1- Askitopoulou Helen Medical School, University of Crete, P.O. Box 2208, 71003, Heraklion, Crete, Greece aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/3(2011-06-01), 356-362 0913-8668 25:3<356 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer