caa a22 4500 445373636 CHVBK 20180317142955.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00540-011-1136-1 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1136-1 Duration of cerebral desaturation time during single-lung ventilation correlates with mini mental state examination score [Elektronische Daten] [Koichi Suehiro, Ryu Okutai] Purpose: Single-lung ventilation (SLV) is thought to reduce regional cerebral oxygen saturation (rSO2). In this study, we evaluated changes in rSO2 during SLV and their correlation with perioperative changes in cognitive function. Methods: Sixty-nine patients participated in this study, each of whom received combined thoracic epidural and general anesthesia. rSO2 was measured using INVOS 5100 (Somanetics, Troy, MI, USA) before anesthesia (baseline value) and until SLV was completed. Patient cognitive function was assessed using the mini mental state examination (MMSE) on the day before surgery (baseline) and then repeated 4days after surgery. The patients were classified into two groups: with (desaturation group, group D) and without (nondesaturation group, group N) cerebral desaturation during SLV. Cerebral desaturation was defined as a reduction of rSO2 during SLV less than 80% of the baseline value. An intergroup comparison was made between perioperative cognitive function findings (MMSE score change between baseline and 4th day after surgery). We also examined the correlation between the duration of desaturation during SLV and perioperative MMSE score changes in group D patients. Results: Seventeen patients were included in group D. The MMSE score decrease was significantly higher in group D as compared to that in group N (P<0.05). The duration of desaturation time was significantly negatively correlated with MMSE score change (r 2=0.444, P<0.05). Conclusion: Duration of cerebral desaturation time during SLV correlates with MMSE score. Additional studies are needed to determine whether intervention against cerebral desaturation during SLV can prevent postoperative cognitive dysfunction. Japanese Society of Anesthesiologists, 2011 Cerebral desaturation nationallicence Single lung ventilation nationallicence Cognitive dysfunction nationallicence Suehiro Koichi Department of Anesthesiology, Osaka City General Hospital and Children Hospital, 2-13-22 Miyakojima-hondori, Miyakojimaku, 534-0021, Osaka, Osaka, Japan aut Okutai Ryu Department of Anesthesiology, Osaka City General Hospital and Children Hospital, 2-13-22 Miyakojima-hondori, Miyakojimaku, 534-0021, Osaka, Osaka, Japan aut Journal of Anesthesia Springer Japan 25/3(2011-06-01), 345-349 0913-8668 25:3<345 2011 25 540 https://doi.org/10.1007/s00540-011-1136-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1136-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suehiro Koichi Department of Anesthesiology, Osaka City General Hospital and Children Hospital, 2-13-22 Miyakojima-hondori, Miyakojimaku, 534-0021, Osaka, Osaka, Japan aut NATIONALLICENCE 700 1- Okutai Ryu Department of Anesthesiology, Osaka City General Hospital and Children Hospital, 2-13-22 Miyakojima-hondori, Miyakojimaku, 534-0021, Osaka, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/3(2011-06-01), 345-349 0913-8668 25:3<345 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer