caa a22 4500 445373768 CHVBK 20180317142956.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1147-y doi (NATIONALLICENCE)springer-10.1007/s00540-011-1147-y The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold [Elektronische Daten] [Joon-Ho Lee, Sung-Hwan Cho, Sang-Hyun Kim, Won-Soek Chae, Hee-Cheol Jin, Jeong-Seok Lee, Yong-Ik Kim] Purpose: We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60ng/ml. Methods: Healthy young volunteers (n=20) were enrolled. A thermode was applied to the volar side of each volunteer's right forearm, and HPT and TST were measured before and after TCI of ketamine. Vital signs and psychedelic effects according to ketamine infusion were also observed before and after TCI of ketamine. Results: Mean HPT after TCI of ketamine with a Ce of 30 and 60ng/ml did not increase significantly. However, mean TST after TCI of ketamine with a Ce of 30 and 60ng/ml increased significantly, in a dose-dependent fashion, compared with the value before ketamine TCI. Vital signs showed no significant difference before and after ketamine TCI. The visual analog scale score of psychedelic symptoms was higher with a Ce of 60 ng/ml than with 30ng/ml. Conclusions: TCI of ketamine with a Ce of 30 and 60ng/ml increased TST but not HPT. Japanese Society of Anesthesiologists, 2011 Heat pain threshold nationallicence Low-dose ketamine nationallicence Quantitative sensory testing nationallicence Temporal summation nationallicence Lee Joon-Ho Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Cho Sung-Hwan Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Kim Sang-Hyun Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Chae Won-Soek Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Jin Hee-Cheol Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Lee Jeong-Seok Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Kim Yong-Ik Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 516-522 0913-8668 25:4<516 2011 25 540 https://doi.org/10.1007/s00540-011-1147-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1147-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Joon-Ho Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 700 1- Cho Sung-Hwan Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 700 1- Kim Sang-Hyun Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 700 1- Chae Won-Soek Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 700 1- Jin Hee-Cheol Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 700 1- Lee Jeong-Seok Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 700 1- Kim Yong-Ik Department of Anesthesiology and Pain Medicine, University of Soonchunhyang, Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, 420-767, Bucheon-Si, Gyeonggi-Do, Korea aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 516-522 0913-8668 25:4<516 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer