caa a22 4500 445373784 CHVBK 20180317142956.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1157-9 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1157-9 The effect of oral clonidine premedication on blood loss and the quality of the surgical field during endoscopic sinus surgery: a placebo-controlled clinical trial [Elektronische Daten] [Masood Mohseni, Amin Ebneshahidi] Bleeding during functional endoscopic sinus surgery (FESS) remains a challenge for both surgeons and anesthesiologists despite several modalities available for improving the surgical field. This study was conducted to evaluate the effect of oral clonidine premedication on blood loss and the quality of the surgical field in FESS. In a placebo-controlled clinical trial, a total of 84 American Society of Anesthesiologists (ASA) physical status I-II patients undergoing endoscopic sinus surgery for chronic sinusitis were randomly allocated to receive either oral clonidine 0.2mg or identical-looking placebo tablets 90min before arrival at the operating room. Blood loss in the clonidine group was 214±67ml on average and that in the placebo group was 276±78ml (mean±SD, p<0.01). The median (range) bleeding score in the clonidine group was significantly lower than that in the placebo group (2 (1-3) vs. 2.5 (2-4), p<0.0001). Accordingly, the surgeon was more satisfied with the surgical field in the clonidine group than with that in the placebo group (median score, 4 (3-5) vs. 3 (1-5), p<0.001). In conclusion, premedication with oral clonidine 0.2mg can effectively reduce bleeding during FESS. Japanese Society of Anesthesiologists, 2011 Clonidine nationallicence Endoscopy nationallicence Otorhinolaryngologic surgical procedure nationallicence Paranasal sinuses nationallicence Hemorrhage nationallicence Mohseni Masood Department of Anesthesiology, Sadi Hospital, Khodaverdi Alley, Sadi Blv, Isfahan, Iran aut Ebneshahidi Amin Department of Anesthesiology, Sadi Hospital, Khodaverdi Alley, Sadi Blv, Isfahan, Iran aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 614-617 0913-8668 25:4<614 2011 25 540 https://doi.org/10.1007/s00540-011-1157-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1157-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mohseni Masood Department of Anesthesiology, Sadi Hospital, Khodaverdi Alley, Sadi Blv, Isfahan, Iran aut NATIONALLICENCE 700 1- Ebneshahidi Amin Department of Anesthesiology, Sadi Hospital, Khodaverdi Alley, Sadi Blv, Isfahan, Iran aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 614-617 0913-8668 25:4<614 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer