caa a22 4500 445373792 CHVBK 20180317142956.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1174-8 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1174-8 Administration of dexmedetomidine alone during diagnostic cardiac catheterization in adults with congenital heart disease: two case reports [Elektronische Daten] [Takayuki Kunisawa, Atsushi Kurosawa, Dai Hayashi, Keiya Takahashi, Mai Kishi, Hiroshi Iwasaki] We report the clinical management of 2 adults with mental retardation because of trisomy 21 who were sedated with high-dose dexmedetomidine (DEX) alone during diagnostic cardiac catheterization (DCC). The first patient was a 25-year-old man with aortic regurgitation and ventricular septal defect. DEX increased his Ramsay sedation score; however, a high dose and bolus injection of DEX were required to perform an invasive procedure. Cardiovascular drugs were not administered and heart rate was maintained in the low 40s. The maximum predicted plasma concentration (pCp) of DEX was 2.3ng/mL. The second patient was a 26-year-old woman who had developed hypoxia 20years after palliative surgery for tetralogy of Fallot. High-dose DEX was administered to keep the bispectral index value below 70 and maintain an immobile state; her maximum pCp of DEX was 4.3ng/mL. Percutaneous oxygen saturation was kept above 83%, because of the suspicion that DEX may increase the ratio of pulmonary artery flow to systemic artery flow. In both cases, no respiratory system complications occurred despite inspiration of room air, indicating the usefulness of DEX for DCC. However, because of DEX may affect DCC data, it is necessary to pay careful attention to the use of DEX during DCC. Japanese Society of Anesthesiologists, 2011 Dexmedetomidine nationallicence Diagnostic cardiac catheterization nationallicence Congenital heart disease nationallicence Kunisawa Takayuki Surgical Operation Department, Asahikawa Medical College Hospital, 0788510, Asahikawa, Hokkaido, Japan aut Kurosawa Atsushi Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut Hayashi Dai Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut Takahashi Keiya Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut Kishi Mai Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut Iwasaki Hiroshi Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 599-602 0913-8668 25:4<599 2011 25 540 https://doi.org/10.1007/s00540-011-1174-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1174-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kunisawa Takayuki Surgical Operation Department, Asahikawa Medical College Hospital, 0788510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Kurosawa Atsushi Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Hayashi Dai Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Takahashi Keiya Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Kishi Mai Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Iwasaki Hiroshi Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-higashi, 0788510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 599-602 0913-8668 25:4<599 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer