caa a22 4500 445373814 CHVBK 20180317142956.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1141-4 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1141-4 Intrathecal neurolytic block in a patient with refractory cancer pain [Elektronische Daten] [Akihiko Watanabe, Michiaki Yamakage] We report the successful treatment of refractory cancer pain by bilateral intrathecal neurolysis using phenol-glycerol. A 60-year-old man had recurrent sigmoid cancer and metastases to the lumbar (L4-5) and sacral bones. He complained of refractory pain in the lower back and lower extremities despite high-dose opioid treatment based on the WHO ladder. On admission to our hospital, he received continuous intravenous infusion of morphine (7,000mg/day) with ketamine (300mg/day) and lidocaine (700mg/day). Intravenous midazolam was required to treat extreme anxiety. Because of inadequate pain relief and severe drowsiness, intrathecal phenol-glycerol neurolytic block was performed twice at the L2/3 intervertebral space. His analgesia was greatly improved and high-dose intravenous opioid was retitrated and ceased. He remained comfortable and lucid at home for 2months, until 2days before his death at hospital. Intrathecal neurolytic block may be appropriate for some patients suffering from refractory pain that is resistant to conventional opioid analgesic treatment. Japanese Society of Anesthesiologists, 2011 Cancer pain nationallicence Neurolytic block nationallicence Phenol-glycerol nationallicence Watanabe Akihiko Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Hokkaido, Japan aut Yamakage Michiaki Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Hokkaido, Japan aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 603-605 0913-8668 25:4<603 2011 25 540 https://doi.org/10.1007/s00540-011-1141-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1141-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watanabe Akihiko Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Yamakage Michiaki Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, 060-8543, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 603-605 0913-8668 25:4<603 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer