caa a22 4500 445373830 CHVBK 20180317142956.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1173-9 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1173-9 Human brain activity associated with painful mechanical stimulation to muscle and bone [Elektronische Daten] [Lynn Maeda, Mayu Ono, Tetsuo Koyama, Yoshitetsu Oshiro, Masahiko Sumitani, Takashi Mashimo, Masahiko Shibata] Purpose: The purpose of this study was to elucidate the central processing of painful mechanical stimulation to muscle and bone by measuring blood oxygen level-dependent signal changes using functional magnetic resonance imaging (fMRI). Methods: Twelve healthy volunteers were enrolled. Mechanical pressure on muscle and bone were applied at the right lower leg by an algometer. Intensities were adjusted to cause weak and strong pain sensation at either target site in preliminary testing. Brain activation in response to mechanical nociceptive stimulation targeting muscle and bone were measured by fMRI and analyzed. Results: Painful mechanical stimulation targeting muscle and bone activated the common areas including bilateral insula, anterior cingulate cortex, posterior cingulate cortex, secondary somatosensory cortex (S2), inferior parietal lobe, and basal ganglia. The contralateral S2 was more activated by strong stimulation than by weak stimulation. Some areas in the basal ganglia (bilateral putamen and caudate nucleus) were more activated by muscle stimulation than by bone stimulation. Conclusions: The putamen and caudate nucleus may have a more significant role in brain processing of muscle pain compared with bone pain. Japanese Society of Anesthesiologists, 2011 Pain nationallicence Muscle nationallicence Bone nationallicence Neuroimaging nationallicence fMRI nationallicence Maeda Lynn Department of Anesthesia and Pain Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan aut Ono Mayu Department of Anesthesia, Ikeda City Hospital, Ikeda, Japan aut Koyama Tetsuo Department of Rehabilitation, Kyoritsu Neurosurgery Hospital, Nishinomiya, Japan aut Oshiro Yoshitetsu Himeji Ishikawa Functional Brain Imaging Laboratory, Himeji, Japan aut Sumitani Masahiko Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan aut Mashimo Takashi Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan aut Shibata Masahiko Department of Pain Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 523-530 0913-8668 25:4<523 2011 25 540 https://doi.org/10.1007/s00540-011-1173-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1173-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maeda Lynn Department of Anesthesia and Pain Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Ono Mayu Department of Anesthesia, Ikeda City Hospital, Ikeda, Japan aut NATIONALLICENCE 700 1- Koyama Tetsuo Department of Rehabilitation, Kyoritsu Neurosurgery Hospital, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Oshiro Yoshitetsu Himeji Ishikawa Functional Brain Imaging Laboratory, Himeji, Japan aut NATIONALLICENCE 700 1- Sumitani Masahiko Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Mashimo Takashi Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Shibata Masahiko Department of Pain Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 523-530 0913-8668 25:4<523 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer