caa a22 4500 445373911 CHVBK 20180317142956.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1143-2 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1143-2 Effect of fentanyl on ischemic depolarization and ischemic neuronal damage of hippocampal CA1 in the gerbil [Elektronische Daten] [Kensuke Shiraishi, Yoshimasa Takeda, Kenichi Masui, Hideki Taninishi, Toshihiro Sasaki, Tetsuya Danura, Kiyoshi Morita] Purpose: Temporary brain ischemia occurring during surgery under general anesthesia may induce the death of neuronal cells and cause severe neurological deficits. On the other hand, it is not clear whether μ-opioid receptor agonists promote ischemic brain injury. It is known that duration of ischemic depolarization affects the degree of neuronal damage. However, the effects of fentanyl during brain ischemia on ischemic depolarization have not been investigated. Therefore, in the current study, the effects of fentanyl on ischemic neuronal damage and ischemic depolarization were quantitatively evaluated. Methods: Forty-two male gerbils were randomly assigned to a saline-administered group (control group, n=21) and a fentanyl-administered group (fentanyl group, n=21). Fentanyl at 50 μg/kg was first administered over a 10-min period and then 50μg/kg/h was administered continuously for the fentanyl group. Forebrain ischemia was initiated by occlusion of bilateral common carotid arteries and sustained for 3, 5, or 7min (n=7 in each group). Direct-current potentials were measured in bilateral CA1 regions, in which histological evaluation was performed 5days later. Results: There were no significant differences in onset time, duration of ischemic depolarization, and percentage of neuronal damage between the two groups with any ischemic duration. In the relationships between ischemic time and neuronal damage and those between duration of ischemic depolarization and neuronal damage, there was no significant difference in the percentage of neuronal damage between the two groups. Conclusion: Fentanyl at a clinically relevant dose does not affect ischemic depolarization and ischemic neuronal damage. Japanese Society of Anesthesiologists, 2011 Fentanyl nationallicence Brain ischemia nationallicence Neuronal damage nationallicence Ischemic depolarization nationallicence μ-Opioid receptor nationallicence Shiraishi Kensuke Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut Takeda Yoshimasa Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut Masui Kenichi Department of Anesthesiology, National Defense Medical College, Tokorozawa, Japan aut Taninishi Hideki Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut Sasaki Toshihiro Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut Danura Tetsuya Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut Morita Kiyoshi Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 540-548 0913-8668 25:4<540 2011 25 540 https://doi.org/10.1007/s00540-011-1143-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1143-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shiraishi Kensuke Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut NATIONALLICENCE 700 1- Takeda Yoshimasa Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut NATIONALLICENCE 700 1- Masui Kenichi Department of Anesthesiology, National Defense Medical College, Tokorozawa, Japan aut NATIONALLICENCE 700 1- Taninishi Hideki Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut NATIONALLICENCE 700 1- Sasaki Toshihiro Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut NATIONALLICENCE 700 1- Danura Tetsuya Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut NATIONALLICENCE 700 1- Morita Kiyoshi Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Okayama, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 540-548 0913-8668 25:4<540 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer