caa a22 4500 445374071 CHVBK 20180317142957.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00540-011-1163-y doi (NATIONALLICENCE)springer-10.1007/s00540-011-1163-y Possible link between cyclooxygenase-inhibiting and antitumor properties of propofol [Elektronische Daten] [Takefumi Inada, Kozue Kubo, Koh Shingu] The intravenous anesthetic propofol has a number of well-known nonanesthetic effects, including anti-oxidation and anti-emesis. Another interesting nonanesthetic effect of propofol may be its cyclooxygenase (COX)-inhibiting activity. This activity may have important clinical implications, as propofol could have antitumor properties through COX inhibition. Propofol could counteract the activity of COX, which elicits, via its major product prostaglandin E2, (1) tumor growth stimulation, (2) increased tumor survival, (3) enhanced tumor invasiveness, (4) stimulation of new vessel formation, and (5) tumor evasion of host immune surveillance through suppression of immune cell functions. Indeed, accumulated evidence indicates that propofol suppresses the proliferation, motility, and invasiveness of tumors in vitro and in vivo. Therefore, propofol could be a particularly suitable anesthetic for use during the perioperative period for cancer surgery. However, whether the COX-inhibiting activity of propofol is related to the reported antitumor properties of propofol is not known. Definitive evidence remains to be provided. Japanese Society of Anesthesiologists, 2011 Antitumor property nationallicence Cyclooxygenase nationallicence Immune cells nationallicence Metastasis nationallicence Propofol nationallicence Prostaglandin E2 nationallicence Inada Takefumi Department of Anesthesiology, Kansai Medical University, 10-15, Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan aut Kubo Kozue Department of Anesthesiology, Kansai Medical University, 10-15, Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan aut Shingu Koh Department of Anesthesiology, Kansai Medical University, 10-15, Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan aut Journal of Anesthesia Springer Japan 25/4(2011-08-01), 569-575 0913-8668 25:4<569 2011 25 540 https://doi.org/10.1007/s00540-011-1163-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1163-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inada Takefumi Department of Anesthesiology, Kansai Medical University, 10-15, Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan aut NATIONALLICENCE 700 1- Kubo Kozue Department of Anesthesiology, Kansai Medical University, 10-15, Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan aut NATIONALLICENCE 700 1- Shingu Koh Department of Anesthesiology, Kansai Medical University, 10-15, Fumizono-cho, 570-8507, Moriguchi, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/4(2011-08-01), 569-575 0913-8668 25:4<569 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer