caa a22 4500 44537411X CHVBK 20180317142957.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00540-011-1208-2 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1208-2 The effect of patient-controlled intravenous analgesia on postoperative hypokalemia in patients undergoing laparoscopic cholecystectomy [Elektronische Daten] [Won Kim, Jong Lee, Justin Ko, Tae Hahm, Sangmin Lee, Hyun Cho] Purpose: We investigated whether hypokalemia developed during the postoperative period and whether the use of intravenous patient-controlled analgesia (IV-PCA) could decrease the incidence of postoperative hypokalemia in patients who underwent laparoscopic cholecystectomy. Methods: Sixty patients undergoing laparoscopic cholecystectomy were randomly assigned to either IV-PCA (n=30) or control (n=30) groups. We measured serum potassium concentration at the outpatient department (T1), at 8:00a.m. on the day of surgery (T2), at 6h after the end of surgery (T3), and at 8:00a.m. on the first (T4), second (T5), and third (T6) postoperative days. Serum potassium concentration, incidence of hypokalemia, mean blood pressure, heart rate, respiratory rate, and the patient-reported visual analogue scale score were compared within each group and between groups at each time point. Results: Serum potassium concentrations in all patients showed a significant decrease at T2-T4 compared to the preoperative concentration (T1). Serum potassium concentrations at T3 and T4 in the IV-PCA group were significantly higher than those in the control group. Also, the incidence of hypokalemia at T3 and T4 was significantly lower in the IV-PCA group. Mean blood pressure and heart rate were significantly lower in the IV-PCA group than in controls at T3 and T4. Conclusions: The results show that hypokalemia developed during the perioperative period and the use of IV-PCA in patients undergoing laparoscopic cholecystectomy effectively decreased the degree and incidence of postoperative hypokalemia on the day of the operation and postoperative day one. Japanese Society of Anesthesiologists, 2011 Patient-controlled intravenous analgesia nationallicence Hypokalemia nationallicence Arrhythmia nationallicence Catecholamine nationallicence Laparoscopic cholecystectomy nationallicence Kim Won Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut Lee Jong Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut Ko Justin Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut Hahm Tae Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut Lee Sangmin Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut Cho Hyun Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut Journal of Anesthesia Springer Japan 25/5(2011-10-01), 685-691 0913-8668 25:5<685 2011 25 540 https://doi.org/10.1007/s00540-011-1208-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1208-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Won Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Jong Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Ko Justin Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Hahm Tae Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Sangmin Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Cho Hyun Department of Anesthesiology and Pain Medicine, Samsung Seoul Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Kangnam-Gu, 135-710, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/5(2011-10-01), 685-691 0913-8668 25:5<685 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer