caa a22 4500 445374195 CHVBK 20180317142957.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00540-011-1206-4 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1206-4 A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery [Elektronische Daten] [Richard D'Alonzo, Elliott Bennett-Guerrero, Mihai Podgoreanu, Thomas D'Amico, David Harpole, Andrew Shaw] Purpose: We hypothesized that patients who received ketamine during thoracic surgery would benefit from suppression of the inflammatory cascade, represented by lower interleukin (IL)-6 and C-reactive protein (CRP) plasma levels. Methods: This study was a randomized, double blind, placebo controlled clinical trial of ketamine in patients undergoing thoracic surgery. The setting was a single university teaching hospital. Forty patients who presented to the preoperative clinic prior to thoracic surgery (20 control, 20 treatment) were randomized to receive either a 0.5mg/kg ketamine bolus or an equivalent volume of normal saline intravenously prior to chest wall incision. Plasma samples taken prior to induction of anesthesia and at 24h following surgery were assayed for IL-6 and CRP levels. Verbal pain scores were reported at 4 and 24h following surgery and at discharge. Results: IL-6 plasma levels did not differ significantly at 24h for patients receiving ketamine (245±287pg/ml, mean±SD) compared to patients who received placebo (269±210pg/ml), p=0.39. Additionally, CRP levels at 24h were not significantly different (8.8±4.5mg/dl for ketamine, 9.3±5.6mg/dl for placebo patients), p=0.37. Finally, verbal pain scores were not significantly different between patient groups at 4 or 24h, or at discharge. Conclusions: These findings suggest that the routine use of a single dose of ketamine prior to chest wall incision is not effective at reducing pain or inflammation in thoracic surgery patients at 24h postoperatively. Japanese Society of Anesthesiologists, 2011 Ketamine nationallicence Thoracic surgery nationallicence Acute pain nationallicence IL-6 nationallicence CRP nationallicence D'Alonzo Richard Department of Anesthesiology, Pitt Count Memorial Hospital, 27858, Greenville, NC, USA aut Bennett-Guerrero Elliott Division of Cardiothoracic and Critical Care Anesthesia, Department of Anesthesiology, Duke University Medical Center, Box 3094, 27710, Durham, NC, USA aut Podgoreanu Mihai Division of Cardiothoracic and Critical Care Anesthesia, Department of Anesthesiology, Duke University Medical Center, Box 3094, 27710, Durham, NC, USA aut D'Amico Thomas Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Box 3707 DUMC, 27710, Durham, NC, USA aut Harpole David Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Box 3707 DUMC, 27710, Durham, NC, USA aut Shaw Andrew Division of Cardiothoracic and Critical Care Anesthesia, Department of Anesthesiology, Duke University Medical Center, Box 3094, 27710, Durham, NC, USA aut Journal of Anesthesia Springer Japan 25/5(2011-10-01), 672-678 0913-8668 25:5<672 2011 25 540 https://doi.org/10.1007/s00540-011-1206-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1206-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D'Alonzo Richard Department of Anesthesiology, Pitt Count Memorial Hospital, 27858, Greenville, NC, USA aut NATIONALLICENCE 700 1- Bennett-Guerrero Elliott Division of Cardiothoracic and Critical Care Anesthesia, Department of Anesthesiology, Duke University Medical Center, Box 3094, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Podgoreanu Mihai Division of Cardiothoracic and Critical Care Anesthesia, Department of Anesthesiology, Duke University Medical Center, Box 3094, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- D'Amico Thomas Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Box 3707 DUMC, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Harpole David Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Box 3707 DUMC, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Shaw Andrew Division of Cardiothoracic and Critical Care Anesthesia, Department of Anesthesiology, Duke University Medical Center, Box 3094, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/5(2011-10-01), 672-678 0913-8668 25:5<672 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer