caa a22 4500 44537425X CHVBK 20180317142957.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00540-011-1190-8 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1190-8 El Tahan Mohamed Anesthesiology Department, College of Medicine, University of Dammam, P.O. 40289, 31952, Dammam, Al Khobar, Saudi Arabia aut Effects of aminophylline on cognitive recovery after sevoflurane anesthesia [Elektronische Daten] [Mohamed El Tahan] Purpose: Aminophylline accelerates the recovery from sevoflurane anesthesia. We studied the effects of escalating doses of aminophylline on cognitive and clinical recovery after sevoflurane anesthesia. Methods: After ethical approval and informed consent, 150 patients scheduled for elective surgery under sevoflurane-fentanyl anesthesia were randomly allocated to receive saline or 2, 3, 4 or 5mg/kg of aminophylline (n=30 for each) at the end of anesthesia (T 0). Short Orientation Memory Concentration Test (SOMCT) scores, entropy values, end-tidal sevoflurane concentrations (EtSevo), times to eyes opening and extubation, respiratory rate (RR) and tidal volume (TV) were recorded. Results: Compared to placebo, patients receiving 2, 3, 4 and 5mg/kg of aminophylline had higher SOMCT scores [median (25th percentile/75th percentile) 20.6 (19/23), 21.5 (21/22), 24.5 (24-25), 25.5 (25/26), respectively, vs. 13.5 (13/14) at 30min after extubation, and 24 (22/26), 25 (24/26), 27.5 (27-28), 27.5 (27/28), respectively, vs. 18.5 (18/19) at 45min after extubation], higher entropy values for the first 10min after T 0, lower EtSevo for the first 4min after T 0, shorter times to eyes opening [5 (4.0/6.0), 5 (4.0/6.0), 4 (2.0/5.5), and 4 (2.0/6.0), respectively, vs. 9.8 (8.0/11.0)min], shorter times to extubation, shorter times to home discharge (P<0.001), and higher RR and larger TV values. Patients who received 4 and 5mg/kg of aminophylline showed higher SOMCT scores, 6min shorter times to eyes opening and to extubation, and 58min shorter times to home discharge. Conclusion: The administration of escalating doses of aminophylline accelerates postoperative cognitive recovery from sevoflurane anesthesia, as measured by the SOMCT, due to increased ventilatory elimination of sevoflurane. Japanese Society of Anesthesiologists, 2011 Aminophylline nationallicence Sevoflurane nationallicence Anesthesia nationallicence Cognitive function nationallicence Recovery nationallicence Entropy nationallicence Journal of Anesthesia Springer Japan 25/5(2011-10-01), 648-656 0913-8668 25:5<648 2011 25 540 https://doi.org/10.1007/s00540-011-1190-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1190-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- El Tahan Mohamed Anesthesiology Department, College of Medicine, University of Dammam, P.O. 40289, 31952, Dammam, Al Khobar, Saudi Arabia aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/5(2011-10-01), 648-656 0913-8668 25:5<648 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer