caa a22 4500 445374314 CHVBK 20180317142958.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00540-011-1192-6 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1192-6 Flurbiprofen axetil enhances analgesic effect of fentanyl associated with increase in β-endorphin levels [Elektronische Daten] [Zhao-Fang Liu, Xiao-Qing Chai, Kun-Zhou Chen] Purpose: To examine the analgesic effect of preoperative administration of flurbiprofen axetil and that of postoperative administration of a combination of flurbiprofen axetil and fentanyl, as well as perioperative plasma β-endorphin (β-EP) levels in patients undergoing esophagectomy. Methods: Forty-five patients were randomly divided into three groups: group A: 100mg flurbiprofen axetil preoperative, 10μg/kg fentanyl+10ml placebo postoperative; group B: 100mg flurbiprofen axetil preoperative, 10μg/kg fentanyl+100mg flurbiprofen axetil postoperative; group C: 10ml placebo preoperative, 10μg/kg fentanyl+10ml placebo postoperative. Postoperative analgesia was achieved by intravenous infusion containing flurbiprofen axetil and/or fentanyl at 2.0ml/h (total volume, 100ml) using infusion pumps. The β-EP was measured at preanesthesia (T1), the end of surgery (T2), 24h (T3), and 48h (T4) after surgery. Visual analog scale scores (VAS) at T3, T4 (at rest), and rescue analgesic tramadol requirement was recorded. Results: The VAS of group B was significantly lower than group A and C (P<0.01) at T3 and T4. The β-EP levels at T2-T4 in group A did not differ significantly from those at T1 (P>0.05); however, the β-EP levels in group B at T3-T4 increased significantly (P<0.05), while those in group C increased at T2 and decreased at T4 (P<0.05). The β-EP levels in group B at T3 and T4 were the highest as compared to its levels in groups A and C (P<0.01). Tramadol consumption in group B was significantly lower than in groups A and C (P<0.01). Conclusion: These results show that flurbiprofen axetil enhances the analgesic effect of fentanyl associated with increase in β-EP levels. Japanese Society of Anesthesiologists, 2011 Flurbiprofen nationallicence Fentanyl nationallicence β-Endorphin nationallicence Analgesic nationallicence Liu Zhao-Fang Department of Anesthesiology, Yijishan Hospital of Wannan Medical College, 241001, Wuhu, China aut Chai Xiao-Qing Department of Anesthesiology, Anhui Provincial Hospital, 230001, Hefei, China aut Chen Kun-Zhou Department of Anesthesiology, Anhui Provincial Hospital, 230001, Hefei, China aut Journal of Anesthesia Springer Japan 25/5(2011-10-01), 679-684 0913-8668 25:5<679 2011 25 540 https://doi.org/10.1007/s00540-011-1192-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1192-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Zhao-Fang Department of Anesthesiology, Yijishan Hospital of Wannan Medical College, 241001, Wuhu, China aut NATIONALLICENCE 700 1- Chai Xiao-Qing Department of Anesthesiology, Anhui Provincial Hospital, 230001, Hefei, China aut NATIONALLICENCE 700 1- Chen Kun-Zhou Department of Anesthesiology, Anhui Provincial Hospital, 230001, Hefei, China aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/5(2011-10-01), 679-684 0913-8668 25:5<679 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer