caa a22 4500 445374454 CHVBK 20180317142958.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00540-011-1203-7 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1203-7 Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia [Elektronische Daten] [Masafumi Kimura, Tomonori Okamoto, Hiroshi Tsukagoshi, Jun Sato, Shigeru Saito] Purpose: Nausea and emesis frequently arise during cesarean section performed under spinal or epidural anesthesia, particularly after delivery. We have evaluated the treatment effects of flurbiprofen, metoclopramide and droperidol on nausea and emesis during cesarean section in patients under combined spinal and epidural anesthesia. Methods: The patient cohort comprised 361 patients with American Society of Anesthesiologists (ASA) physical status I or II who elected to undergo cesarean section. All patients received combined spinal-epidural anesthesia. After delivery, nausea and emesis was assessed using a 4-point scale as: 1, excellent, with no complaints; 2, mild nausea; 3, severe nausea; 4, emesis. Patients who experienced severe nausea or emesis were randomly assigned to receive one of the following intravenous drugs: Group A, flurbiprofen (50mg); Group B, metoclopramide (10mg); Group C, droperidol (1.25mg). Effects on nausea and emesis were assessed at 5, 10 and 15min after drug administration using a 4-point scale as: 1, obviously improved; 2, improved; 3, unchanged; 4 worsened. Results: Among the patients, 151 reported nausea or emesis. These patients experienced a longer duration of surgery and anesthesia and lost more blood than patients with no complaints. The frequency of improvement in the flurbiprofen group was significantly higher than that in the metoclopramide group at 5, 10 and 15min (p<0.05) after administration, and of that in the droperidol group at 15min after administration (p<0.05). Conclusion: Intravenous flurbiprofen improves nausea and emesis after delivery by cesarean section more effectively than metoclopramide or droperidol. Japanese Society of Anesthesiologists, 2011 Flurbiprofen nationallicence Nausea and emesis nationallicence Cesarean section nationallicence Spinal anesthesia nationallicence Kimura Masafumi Department of Anesthesiology, Gunma University Hospital, 3-39-15 Showamachi, 371-8511, Maebashi, Gunma, Japan aut Okamoto Tomonori Department of Anesthesiology, Kiryu Welfare Hospital, 6-3 Orihimecho, 376-0024, Kiryu, Gunma, Japan aut Tsukagoshi Hiroshi Department of Anesthesiology, Kiryu Welfare Hospital, 6-3 Orihimecho, 376-0024, Kiryu, Gunma, Japan aut Sato Jun Department of Anesthesiology, Kiryu Welfare Hospital, 6-3 Orihimecho, 376-0024, Kiryu, Gunma, Japan aut Saito Shigeru Department of Anesthesiology, Gunma University Hospital, 3-39-15 Showamachi, 371-8511, Maebashi, Gunma, Japan aut Journal of Anesthesia Springer Japan 25/5(2011-10-01), 692-697 0913-8668 25:5<692 2011 25 540 https://doi.org/10.1007/s00540-011-1203-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1203-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kimura Masafumi Department of Anesthesiology, Gunma University Hospital, 3-39-15 Showamachi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Okamoto Tomonori Department of Anesthesiology, Kiryu Welfare Hospital, 6-3 Orihimecho, 376-0024, Kiryu, Gunma, Japan aut NATIONALLICENCE 700 1- Tsukagoshi Hiroshi Department of Anesthesiology, Kiryu Welfare Hospital, 6-3 Orihimecho, 376-0024, Kiryu, Gunma, Japan aut NATIONALLICENCE 700 1- Sato Jun Department of Anesthesiology, Kiryu Welfare Hospital, 6-3 Orihimecho, 376-0024, Kiryu, Gunma, Japan aut NATIONALLICENCE 700 1- Saito Shigeru Department of Anesthesiology, Gunma University Hospital, 3-39-15 Showamachi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/5(2011-10-01), 692-697 0913-8668 25:5<692 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer