caa a22 4500 445374543 CHVBK 20180317142958.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00540-010-1086-z doi (NATIONALLICENCE)springer-10.1007/s00540-010-1086-z A randomized trial to identify optimal precurarizing dose of rocuronium to avoid precurarization-induced neuromuscular block [Elektronische Daten] [Naoko Fukano, Takahiro Suzuki, Kiyoko Ishikawa, Hitoshi Mizutani, Shigeru Saeki, Setsuro Ogawa] Purpose: The aim of this study was to examine the safe precurarizing dose of rocuronium required to avoid neuromuscular block after precurarization. Methods: Twenty-four female patients were randomly allocated into two groups of 12 patients each. General anesthesia was induced and maintained with remifentanil and propofol, and a laryngeal mask was inserted without the aid of a neuromuscular blocking agent. Patients were randomized to receive either 0.03 or 0.06mg/kg rocuronium as a precurarizing dose. Neuromuscular block was monitored using acceleromyographic train-of-four (TOF) of the adductor pollicis muscle. Three minutes after the precurarization, all patients received suxamethonium 1.5mg/kg and were graded on severity of fasciculations. Results: The average TOF ratio was kept above 0.9 even 3min after precurarization with 0.03mg/kg rocuronium. In contrast, in patients who received 0.06mg/kg rocuronium, the ratios significantly decreased to 0.72 (0.14) [mean (SD), P<0.004] and 0.68 (0.18) (P<0.006) 2min and 3min after the precurarization, respectively. No visible muscle movement was observed following suxamethonium injection, except that one patient who received 0.03mg/kg rocuronium showed very fine muscle movements of the fingertips. Conclusion: Rocuronium at 0.06mg/kg is an overdose for precurarization. The results of the present study demonstrate that a safe and effective precurarizing dose of rocuronium is 0.03mg/kg. Japanese Society of Anesthesiologists, 2011 Precurarization nationallicence Rocuronium nationallicence Suxamethonium nationallicence Neuromuscular block nationallicence Fukano Naoko Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut Suzuki Takahiro Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut Ishikawa Kiyoko Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut Mizutani Hitoshi Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut Saeki Shigeru Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut Ogawa Setsuro Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut Journal of Anesthesia Springer Japan 25/2(2011-04-01), 200-204 0913-8668 25:2<200 2011 25 540 https://doi.org/10.1007/s00540-010-1086-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-010-1086-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fukano Naoko Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Takahiro Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishikawa Kiyoko Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Mizutani Hitoshi Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Saeki Shigeru Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogawa Setsuro Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13, Kanda-Surugadai, Chiyoda-Ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/2(2011-04-01), 200-204 0913-8668 25:2<200 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer