caa a22 4500 445374594 CHVBK 20180317142959.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00540-010-1090-3 doi (NATIONALLICENCE)springer-10.1007/s00540-010-1090-3 Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats [Elektronische Daten] [Lonneke Staals, Hans de Boer, Jan van Egmond, Frank Hope, Francien van de Pol, Anton Bom, Jacques Driessen, Leo Booij] Purpose: Sugammadex is a selective relaxant binding agent designed to encapsulate the aminosteroidal neuromuscular blocking agent rocuronium, thereby reversing its effect. Both sugammadex and the sugammadex-rocuronium complex are eliminated by the kidneys. This study investigated the effect of sugammadex on recovery of rocuronium-induced neuromuscular block in cats with clamped renal pedicles, as a model for acute renal failure. Methods: Twelve male cats were divided into two groups and anesthetized with medetomidine, ketamine, and alpha-chloralose. The cats were intubated and ventilated with a mixture of oxygen and air. Neuromuscular monitoring was performed by single twitch monitoring. Rocuronium 0.5mg/kg i.v. was administered. After spontaneous recovery from neuromuscular block, both renal pedicles were ligated. A second dose of rocuronium 0.5mg/kg i.v. was given. One minute after disappearance of the twitches, in Group 1 placebo (0.9% saline) and in Group 2 sugammadex 5.0mg/kg i.v. was administered. Onset time, duration of neuromuscular block, and time to recovery to 25, 50, 75, and 90% were determined. Results: After renal pedicle ligation, sugammadex reversed rocuronium-induced neuromuscular block significantly faster than spontaneous recovery. Mean time (SEM) to 90% recovery of the twitch response was 4.7 (0.25)min (Group 2) versus 31.1 (5.0)min (Group 1) (p<0.0001). No signs of recurrence of neuromuscular block were observed for 90min after complete twitch restoration. Sugammadex caused no significant cardiovascular effects. Conclusion: Sugammadex rapidly and effectively reversed rocuronium-induced neuromuscular block in anesthetized cats, even when both renal pedicles were ligated and renal elimination of the drugs was no longer possible. Japanese Society of Anesthesiologists, 2011 Kidney failure nationallicence Neuromuscular block nationallicence Antagonism nationallicence Rocuronium nationallicence Sugammadex nationallicence Cat nationallicence Staals Lonneke Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut de Boer Hans Department of Anesthesiology and Pain Medicine, Martini General Hospital, Groningen, The Netherlands aut van Egmond Jan Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Hope Frank Department of Pharmacology, Organon Newhouse, a part of Merck, Sharp and Dohme, ML1 5SH, Lanarkshire, Scotland, UK aut van de Pol Francien Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Bom Anton Department of Pharmacology, Organon Newhouse, a part of Merck, Sharp and Dohme, ML1 5SH, Lanarkshire, Scotland, UK aut Driessen Jacques Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Booij Leo Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Journal of Anesthesia Springer Japan 25/2(2011-04-01), 241-246 0913-8668 25:2<241 2011 25 540 https://doi.org/10.1007/s00540-010-1090-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-010-1090-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Staals Lonneke Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- de Boer Hans Department of Anesthesiology and Pain Medicine, Martini General Hospital, Groningen, The Netherlands aut NATIONALLICENCE 700 1- van Egmond Jan Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Hope Frank Department of Pharmacology, Organon Newhouse, a part of Merck, Sharp and Dohme, ML1 5SH, Lanarkshire, Scotland, UK aut NATIONALLICENCE 700 1- van de Pol Francien Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Bom Anton Department of Pharmacology, Organon Newhouse, a part of Merck, Sharp and Dohme, ML1 5SH, Lanarkshire, Scotland, UK aut NATIONALLICENCE 700 1- Driessen Jacques Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Booij Leo Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/2(2011-04-01), 241-246 0913-8668 25:2<241 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer