caa a22 4500 445374608 CHVBK 20180317142959.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00540-011-1103-x doi (NATIONALLICENCE)springer-10.1007/s00540-011-1103-x Blockade of 5-HT2A and/or 5-HT2C receptors modulates sevoflurane-induced immobility [Elektronische Daten] [Hirokazu Nagatani, Tsutomu Oshima, Akiyoshi Urano, Yuhji Saitoh, Miyuki Yokota, Yoshinori Nakata] Purpose: Blockade of 5-hydroxytryptamine (5-HT)2A receptors reportedly mediates or modulates the ability of isoflurane to produce immobility during noxious stimulation and would thereby influence MAC (the minimum alveolar concentration required to suppress movement in response to noxious stimulation in 50% of subjects). However, no data are yet available regarding the role of this receptor in the immobilizing action of sevoflurane. In this study, we examined how prior intraperitoneal administration of either the 5-HT2A receptor antagonist altanserin or the 5-HT2C/2B receptor antagonist SB 206553 might affect sevoflurane MAC in rats. Methods: Three groups of six male Wistar rats weighing 250-350g each received one of the following drugs dissolved in dimethyl sulfoxide intraperitoneally 30min before MAC testing: (1) altanserin 10mg/kg; (2) SB 206553 10mg/kg; (3) no drug (vehicle control). MAC was defined as the average of the concentrations that just prevented or just permitted movement in response to clamping the tail for 1min. Results: The rank order of MAC values obtained after intraperitoneal drug pretreatment and sevoflurane exposure was altanserin<SB 206553<vehicle control. Conclusion: Considering the low levels of 5-HT2B receptors within the CNS, this result suggests that 5-HT2A and the 5-HT2C receptors are present within the neural circuitry influencing sevoflurane MAC. Blockade of 5-HT2A and/or 5-HT2C receptors may modulate the immobility produced by sevoflurane during noxious stimulation. Japanese Society of Anesthesiologists, 2011 Sevoflurane nationallicence Immobility nationallicence Serotonin nationallicence Nagatani Hirokazu Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut Oshima Tsutomu Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut Urano Akiyoshi Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut Saitoh Yuhji Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut Yokota Miyuki Department of Anesthesiology, Cancer Institute Hospital of JFCR, 3-8-31 Ariake, 135-8550, Koto, Tokyo, Japan aut Nakata Yoshinori Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut Journal of Anesthesia Springer Japan 25/2(2011-04-01), 225-228 0913-8668 25:2<225 2011 25 540 https://doi.org/10.1007/s00540-011-1103-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1103-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nagatani Hirokazu Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut NATIONALLICENCE 700 1- Oshima Tsutomu Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut NATIONALLICENCE 700 1- Urano Akiyoshi Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut NATIONALLICENCE 700 1- Saitoh Yuhji Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut NATIONALLICENCE 700 1- Yokota Miyuki Department of Anesthesiology, Cancer Institute Hospital of JFCR, 3-8-31 Ariake, 135-8550, Koto, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakata Yoshinori Department of Anesthesiology, Teikyo University Chiba Medical Center, 299-0111, Chiba, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/2(2011-04-01), 225-228 0913-8668 25:2<225 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer