caa a22 4500 445374675 CHVBK 20180317142959.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00540-011-1099-2 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1099-2 Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children [Elektronische Daten] [Dilek Özcengiz, Yasemin Gunes, Ozlem Ozmete] Purpose: Several studies have reported that sevoflurane was associated with a relatively high incidence of emergence agitation in children even in the absence of any surgical intervention. The aim of this study was to compare early agitation characteristics of oral melatonin, dexmedetomidine, and midazolam premedication in children who were given sevoflurane anesthesia for esophageal dilatation. Methods: Following Internal Review Board approval and parental informed consent, 100 ASA physical status I-II children (3-9years old) who were scheduled to undergo general anesthesia for esophageal dilatation procedures were enrolled. The patients were randomly assigned to four groups (n=25 in each). The premedications in the groups were saline (group P), dexmedetomidine 2.5μg/kg (group D), 0.5mg/kg midazolam (group MD), and melatonin 0.1mg/kg (group ML), given orally. All premedication drugs were given with paracetamol 2-2.5mg/kg to be easily drinkable 40-45min before anesthesia induction. Anesthesia was maintained with sevoflurane 2-4%, N2O 50% in oxygen. No supplemental analgesic agent was given, and an emergence agitation scale (EAS) was measured on admission to the PACU, then every 5 min, and recorded during the postoperative period: 1, awake and calm, cooperative; 2, crying, requires consoling; 3, irritable/restless, screaming, inconsolable; 4, combative, disoriented, thrashing. Children with an agitation score of 3 or 4 were classified as agitated. Results: There were no significant differences among the four groups demographically. The emergence agitation scale was higher in the placebo group than in the others at 5, 10, and 15min postoperatively (P<0.001). EA was similar among group D, group MD, and group ML. Conclusion: We found that oral melatonin, dexmedetomidine, and midazolam reduced the incidence of emergence agitation in children after sevoflurane anesthesia. Japanese Society of Anesthesiologists, 2011 Melatonin nationallicence Dexmedetomidine nationallicence Midazolam nationallicence Postoperative agitation nationallicence Özcengiz Dilek Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey aut Gunes Yasemin Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey aut Ozmete Ozlem Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey aut Journal of Anesthesia Springer Japan 25/2(2011-04-01), 184-188 0913-8668 25:2<184 2011 25 540 https://doi.org/10.1007/s00540-011-1099-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1099-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Özcengiz Dilek Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey aut NATIONALLICENCE 700 1- Gunes Yasemin Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey aut NATIONALLICENCE 700 1- Ozmete Ozlem Department of Anesthesiology, Medical Faculty, Cukurova University, Balcali, Adana, Turkey aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/2(2011-04-01), 184-188 0913-8668 25:2<184 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer