caa a22 4500 445374713 CHVBK 20180317142959.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00540-011-1097-4 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1097-4 A randomized comparison of different doses of intrathecal levobupivacaine combined with fentanyl for elective cesarean section: prospective, double-blinded study [Elektronische Daten] [Ilkben Gunusen, Semra Karaman, Asuman Sargin, Vicdan Firat] Purpose: Levobupivacaine may produce a sensory and motor block different from that produced by bupivacaine, which is the most popular local anesthetic in parturients undergoing cesarean section. The aim of this study was to investigate the block characteristics, the clinical efficacy, surgeon and patient satisfaction, and hemodynamic effects of using different doses of intrathecal plain levobupivacaine combined with fentanyl. Methods: One hundred twenty women undergoing elective cesarean section with a combined spinal-epidural technique were enrolled. The parturients were randomly assigned to receive one of the following: levobupivacaine 5mg (group 5), 7.5mg (group 7.5) or 10mg (group 10), all combined with fentanyl 25, 15 or 10μg, respectively. Results: Anesthesia was effective in 60, 82.5 and 100% of the patients in the levobupivacaine 5, 7.5 and 10mg groups, respectively. Levobupivacaine 10mg provided longer durations of analgesia and motor block and greater patient and surgeon satisfaction, although the incidence of hypotension was lower in groups 5 and 7.5 than in group 10 (12.5, 17.5 and 42.5%, respectively). Intraoperative epidural supplementation was higher in group 5 than in group 7.5 (40 and 17.5%, respectively), whereas no patients in group 10 were given an epidural bolus dose. Conclusions: The incidence of hypotension was higher in the levobupivacaine 10mg group, even though this group presented more effective anesthesia and greater patient and surgeon satisfaction compared with the levobupivacaine 5 and 7.5mg groups. As a result, we believe that levobupivacaine 7.5mg combined with fentanyl 15μg is suitable for combined spinal-epidural anesthesia in elective cesarean section. Japanese Society of Anesthesiologists, 2011 Levobupivacaine nationallicence Fentanyl nationallicence Combined spinal-epidural anesthesia nationallicence Cesarean section nationallicence Gunusen Ilkben Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut Karaman Semra Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut Sargin Asuman Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut Firat Vicdan Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut Journal of Anesthesia Springer Japan 25/2(2011-04-01), 205-212 0913-8668 25:2<205 2011 25 540 https://doi.org/10.1007/s00540-011-1097-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1097-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gunusen Ilkben Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut NATIONALLICENCE 700 1- Karaman Semra Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut NATIONALLICENCE 700 1- Sargin Asuman Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut NATIONALLICENCE 700 1- Firat Vicdan Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/2(2011-04-01), 205-212 0913-8668 25:2<205 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer