caa a22 4500 445374756 CHVBK 20180317142959.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00540-011-1100-0 doi (NATIONALLICENCE)springer-10.1007/s00540-011-1100-0 The effect of one-lung ventilation upon pulmonary inflammatory responses during lung resection [Elektronische Daten] [Yusuke Sugasawa, Keisuke Yamaguchi, Seiichiro Kumakura, Taisuke Murakami, Toyoki Kugimiya, Kenji Suzuki, Isao Nagaoka, Eiichi Inada] Purpose: One-lung ventilation (OLV) is commonly used during thoracic surgery. Clinical studies using bronchoalveolar lavage fluid analysis have demonstrated that OLV induces pulmonary inflammatory reactions in the ventilated dependent lung. However, few clinical studies have investigated such inflammatory reactions in the dependent lung compared with the collapsed nondependent lung. Here we used a bronchoscopic microsampling method to obtain epithelial lining fluid (ELF) from each lung, and then compared the inflammatory reactions in the dependent lung and the nondependent lung during thoracic surgery. Methods: Twenty adult patients were studied. All patients underwent thoracic surgery using OLV. Propofol and remifentanil were used for total intravenous anesthesia. A double-lumen endotracheal tube was used to perform OLV. ELF was obtained from each lung using the bronchoscopic microsampling method. ELF levels of inflammatory mediators, tumor necrosis factor α, interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-12p70 were measured using ELISA before and after OLV. Results: ELF levels of IL-1β, IL-6, and IL-8 were significantly increased in the dependent lung and the nondependent lung at the end of surgery compared with their baseline levels (p<0.05). ELF level of IL-6 was significantly higher in the dependent lung than in the nondependent lung at the end of surgery (p=0.019). Conclusions: One-lung ventilation induced inflammatory responses of the bronchial epithelia in the dependent lung and the nondependent lung during thoracic surgery. In addition, these inflammatory responses were more augmented in the dependent lung than in the nondependent lung. Japanese Society of Anesthesiologists, 2011 One-lung ventilation nationallicence Epithelial lining fluid nationallicence Bronchoscopic microsampling nationallicence Pulmonary inflammation nationallicence Cytokine nationallicence Sugasawa Yusuke Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Yamaguchi Keisuke Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Kumakura Seiichiro Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Murakami Taisuke Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Kugimiya Toyoki Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Suzuki Kenji Department of General Thoracic Surgery, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Nagaoka Isao Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Inada Eiichi Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut Journal of Anesthesia Springer Japan 25/2(2011-04-01), 170-177 0913-8668 25:2<170 2011 25 540 https://doi.org/10.1007/s00540-011-1100-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-011-1100-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugasawa Yusuke Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamaguchi Keisuke Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Kumakura Seiichiro Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Murakami Taisuke Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Kugimiya Toyoki Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Kenji Department of General Thoracic Surgery, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagaoka Isao Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 700 1- Inada Eiichi Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, 113-8431, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/2(2011-04-01), 170-177 0913-8668 25:2<170 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer