caa a22 4500 44537599X CHVBK 20180317143002.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00702-010-0478-4 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0478-4 Luo Yu National Institute on Drug Abuse, I.R.P., 251 Bayview BLVD, 21224, Baltimore, MD, USA aut Cell-based therapy for stroke [Elektronische Daten] [Yu Luo] Current treatments for stroke, such as the use of thrombolytic agents, are often limited by a narrow therapeutic time window. However, the regeneration of the brain after damage is still active days even weeks after stroke occurs, which might provide a second window for treatment. Cell-based therapy can be categorized into two strategies. One is transplantation of exogenous cells into the injured brain to replace the lost cells or support the remaining cells. The other strategy is to enhance the proliferation, differentiation, migration of endogenous stem or progenitor cells. Recent development in adult stem cell research and advancement in the induction of pluripotent stem cells from somatic adult cells provide a tremendous opportunity for transplantation therapy. Understanding the mechanisms and regulations involved in the endogenous neurogenesis will also help develop novel therapeutic interventions to promote neurogenesis and functional recovery in stroke. This review describes up-to-date progresses in cell-based therapy for the treatment of stroke. Springer-Verlag (outside the USA), 2010 Stroke nationallicence Cell-based therapy nationallicence Stem cells nationallicence iPS cells nationallicence Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 61-74 0300-9564 118:1<61 2011 118 702 https://doi.org/10.1007/s00702-010-0478-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0478-4 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Luo Yu National Institute on Drug Abuse, I.R.P., 251 Bayview BLVD, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 61-74 0300-9564 118:1<61 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer