caa a22 4500 445376058 CHVBK 20180317143002.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00702-010-0476-6 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0476-6 Transgenic animal models of neurodegeneration based on human genetic studies [Elektronische Daten] [Brandon Harvey, Christopher Richie, Barry Hoffer, Mikko Airavaara] The identification of genes linked to neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and Parkinson's disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease. Springer-Verlag (outside the USA), 2010 ALS nationallicence PD nationallicence AD nationallicence HD nationallicence Huntington's disease nationallicence Parkinson's disease nationallicence Amyotrophic lateral sclerosis nationallicence Alzheimer's disease nationallicence Transgenic nationallicence Animal model nationallicence Neurodegeneration nationallicence Genetic linkage nationallicence Harvey Brandon Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut Richie Christopher Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut Hoffer Barry Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut Airavaara Mikko Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 27-45 0300-9564 118:1<27 2011 118 702 https://doi.org/10.1007/s00702-010-0476-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0476-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harvey Brandon Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Richie Christopher Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Hoffer Barry Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Airavaara Mikko Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 27-45 0300-9564 118:1<27 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer