caa a22 4500 445376066 CHVBK 20180317143002.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00702-010-0484-6 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0484-6 New aspects of the molecular constituents of tissue barriers [Elektronische Daten] [H. Bauer, A. Traweger, J. Zweimueller-Mayer, C. Lehner, H. Tempfer, I. Krizbai, I. Wilhelm, H. Bauer] Epithelial and endothelial tissue barriers are based on tight intercellular contacts (Tight Junctions, TJs) between neighbouring cells. TJs are multimeric complexes, located at the most apical border of the lateral membrane. So far, a plethora of proteins locating at tight intercellular contacts have been discovered, the role of which has just partly been unraveled. Yet, there is convincing evidence that many TJ proteins exert a dual role: They act as structural components at the junctional site and they are involved in signalling pathways leading to alterations of gene expression and cell behaviour (migration, proliferation). This review will shortly summarize the classical functions of TJs and TJ-related proteins and will introduce a new category, termed the "non-classical” functions of junctional proteins. A particular focus will be directed towards the nuclear targeting of junctional proteins and the downstream effects elicited by their intranuclear activities. Springer-Verlag, 2010 Tissue-barriers nationallicence Epithelia nationallicence Endothelia nationallicence Tight junctions nationallicence Bauer H. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria aut Traweger A. Baxter Innovations GmbH, 2304, Orth an der Donau, Austria aut Zweimueller-Mayer J. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria aut Lehner C. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria aut Tempfer H. Paracelsus Private Medical University, Müllner Hauptstrasse 48, 5020, Salzburg, Austria aut Krizbai I. Biological Research Center, Institute of Biophysics, Temesvari krt 62, 6726, Szeged, Hungary aut Wilhelm I. Biological Research Center, Institute of Biophysics, Temesvari krt 62, 6726, Szeged, Hungary aut Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 7-21 0300-9564 118:1<7 2011 118 702 https://doi.org/10.1007/s00702-010-0484-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0484-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bauer H. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria aut NATIONALLICENCE 700 1- Traweger A. Baxter Innovations GmbH, 2304, Orth an der Donau, Austria aut NATIONALLICENCE 700 1- Zweimueller-Mayer J. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria aut NATIONALLICENCE 700 1- Lehner C. Department of Organismic Biology, University of Salzburg, Hellbrunner Strasse 34, 5020, Salzburg, Austria aut NATIONALLICENCE 700 1- Tempfer H. Paracelsus Private Medical University, Müllner Hauptstrasse 48, 5020, Salzburg, Austria aut NATIONALLICENCE 700 1- Krizbai I. Biological Research Center, Institute of Biophysics, Temesvari krt 62, 6726, Szeged, Hungary aut NATIONALLICENCE 700 1- Wilhelm I. Biological Research Center, Institute of Biophysics, Temesvari krt 62, 6726, Szeged, Hungary aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 7-21 0300-9564 118:1<7 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer