caa a22 4500 445376104 CHVBK 20180317143002.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00702-010-0485-5 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0485-5 CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease [Elektronische Daten] [Rudy Castellani, Summer Nugent, Alan Morrison, Xiongwei Zhu, Hyoung-gon Lee, Peggy Harris, Vladan Bajić, Hari Sharma, Shu Chen, Peter Oettgen, George Perry, Mark Smith] CD3ζ is a subunit of the CD3 molecule that, until recently, appeared restricted to T cells and natural killer cells. However, experimental studies have demonstrated a role of CD3ζ in dendritic outgrowth in the visual system as well as in synaptic plasticity. Given the increasing evidence for uncharacteristic recapitulation of neurodevelopmental processes in neurodegenerative diseases, in this study, we evaluated brains from subjects with Parkinson's disease and Lewy body dementia for evidence of aberrant CD3 expression. Our data shows marked CD3ζ in association with the α-synuclein containing pathological lesions, i.e., Lewy bodies and Lewy neurites, in the brains of subjects with Parkinson's disease and Lewy body dementia. This finding raises the novel concept of CD3 dysregulation in these disorders as a pathogenic factor and also furthers the increasing evidence that the recall of aberrant neurodevelopmental processes underlies the pathogenesis of neurodegenerative diseases. Springer-Verlag, 2010 Alpha-synuclein nationallicence CD3 nationallicence Lewy bodies nationallicence Lewy body dementia nationallicence Lewy neurites nationallicence Neurodevelopment nationallicence Parkinson's disease nationallicence Castellani Rudy Department of Pathology, University of Maryland, 22 South Greene Street, 21201, Baltimore, MD, USA aut Nugent Summer Department of Pathology, University of Maryland, 22 South Greene Street, 21201, Baltimore, MD, USA aut Morrison Alan Department of Pathology, University of Maryland, 22 South Greene Street, 21201, Baltimore, MD, USA aut Zhu Xiongwei Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut Lee Hyoung-gon Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut Harris Peggy Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut Bajić Vladan Institute of Biomedical Research, Galenika a.d, Belgrade, Serbia aut Sharma Hari Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, 75185, Uppsala, Sweden aut Chen Shu Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut Oettgen Peter Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA, USA aut Perry George Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut Smith Mark Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 23-26 0300-9564 118:1<23 2011 118 702 https://doi.org/10.1007/s00702-010-0485-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0485-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Castellani Rudy Department of Pathology, University of Maryland, 22 South Greene Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Nugent Summer Department of Pathology, University of Maryland, 22 South Greene Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Morrison Alan Department of Pathology, University of Maryland, 22 South Greene Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Zhu Xiongwei Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Lee Hyoung-gon Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Harris Peggy Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Bajić Vladan Institute of Biomedical Research, Galenika a.d, Belgrade, Serbia aut NATIONALLICENCE 700 1- Sharma Hari Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, 75185, Uppsala, Sweden aut NATIONALLICENCE 700 1- Chen Shu Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Oettgen Peter Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Perry George Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Smith Mark Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/1(2011-01-01), 23-26 0300-9564 118:1<23 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer