caa a22 4500 445376112 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00702-011-0624-7 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0624-7 The norepinephrine transporter gene is a candidate gene for panic disorder [Elektronische Daten] [H. Buttenschøn, A. Kristensen, H. Buch, J. Andersen, J. Bonde, M. Grynderup, A. Hansen, H. Kolstad, A. Kaergaard, L. Kaerlev, S. Mikkelsen, J. Thomsen, P. Koefoed, A. Erhardt, D. Woldbye, A. Børglum, O. Mors] Panic disorder (PD) is an anxiety disorder characterized by recurrent panic attacks with a lifetime prevalence of 4.7%. Genetic factors are known to contribute to the development of the disorder. Several lines of evidence point towards a major role of the norepinephrine system in the pathogenesis of PD. The SLC6A2 gene is located on chromosome 16q12.2 and encodes the norepinephrine transporter (NET), responsible for the reuptake of norepinephrine into presynaptic nerve terminals. The aim of the present study was to analyze genetic variants located within the NET gene for association with PD. The case-control sample consisted of 449 patients with PD and 279 ethnically matched controls. All cases fulfilled the ICD-10 diagnostic criteria for PD. Genotyping was performed using the Sequenom platform (Sequenom, Inc, San Diego, USA). To test for allelic and haplotypic association, the PLINK software was used, and COMBASSOC was applied to test for gene-wise association. After quality control 29 single nucleotide polymorphisms (SNPs) spanning the gene-region were successfully analyzed. Seven SNPs located within the 5′ end of the gene were significantly associated with PD. Furthermore, the NET gene showed overall evidence for association with the disease (P=0.000035). In conclusion, the present study indicates that NET could be a susceptibility gene for PD. Springer-Verlag, 2011 Panic disorder (PD) nationallicence Association nationallicence Candidate gene nationallicence Norepinephrine transporter ( NET nationallicence SLC6A2 ) nationallicence Single nucleotide polymorphisms (SNPs) nationallicence Buttenschøn H. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut Kristensen A. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut Buch H. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut Andersen J. Department of Occupational Medicine, Danish Ramazzini Centre, Regional Hospital Herning, Herning, Denmark aut Bonde J. Department of Occupational Medicine, Bispebjerg University Hospital, Copenhagen, Denmark aut Grynderup M. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark aut Hansen A. National Research Centre for the Work Environment, Copenhagen, Denmark aut Kolstad H. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark aut Kaergaard A. Department of Occupational Medicine, Danish Ramazzini Centre, Regional Hospital Herning, Herning, Denmark aut Kaerlev L. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark aut Mikkelsen S. Department of Occupational Medicine, Bispebjerg University Hospital, Copenhagen, Denmark aut Thomsen J. Department of Occupational Medicine, Bispebjerg University Hospital, Copenhagen, Denmark aut Koefoed P. Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen and Psychiatric Centre Copenhagen, Copenhagen, Denmark aut Erhardt A. Max Planck Institute of Psychiatry, Munich, Germany aut Woldbye D. Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen and Psychiatric Centre Copenhagen, Copenhagen, Denmark aut Børglum A. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut Mors O. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 969-976 0300-9564 118:6<969 2011 118 702 https://doi.org/10.1007/s00702-011-0624-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0624-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buttenschøn H. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut NATIONALLICENCE 700 1- Kristensen A. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut NATIONALLICENCE 700 1- Buch H. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut NATIONALLICENCE 700 1- Andersen J. Department of Occupational Medicine, Danish Ramazzini Centre, Regional Hospital Herning, Herning, Denmark aut NATIONALLICENCE 700 1- Bonde J. Department of Occupational Medicine, Bispebjerg University Hospital, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Grynderup M. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Hansen A. National Research Centre for the Work Environment, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Kolstad H. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Kaergaard A. Department of Occupational Medicine, Danish Ramazzini Centre, Regional Hospital Herning, Herning, Denmark aut NATIONALLICENCE 700 1- Kaerlev L. Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Mikkelsen S. Department of Occupational Medicine, Bispebjerg University Hospital, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Thomsen J. Department of Occupational Medicine, Bispebjerg University Hospital, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Koefoed P. Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen and Psychiatric Centre Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Erhardt A. Max Planck Institute of Psychiatry, Munich, Germany aut NATIONALLICENCE 700 1- Woldbye D. Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen and Psychiatric Centre Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Børglum A. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut NATIONALLICENCE 700 1- Mors O. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240, Risskov, Denmark aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 969-976 0300-9564 118:6<969 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer