caa a22 4500 445376139 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00702-011-0583-z doi (NATIONALLICENCE)springer-10.1007/s00702-011-0583-z Regulation of the immediate-early genes arc and zif268 in a mouse operant model of cocaine seeking reinstatement [Elektronische Daten] [Barbara Ziółkowska, Michał Kiełbiński, Agnieszka Gieryk, Guadalupe Soria, Rafael Maldonado, Ryszard Przewłocki] Reinstatement of extinguished operant responding for drug is an appropriate model of relapse to drug abuse. Due to the difficulty of implementing in mice the procedure of instrumental intravenous self-administration, mechanisms of reinstatement have so far been studied almost exclusively in rats. A mouse model of reinstatement of cocaine seeking has recently been characterized (Soria et al. 2008). The aim of the present study was to assess regional brain activation, as measured by induction of the immediate early genes (IEG) arc and zif268, during priming- or cue-elicited reinstatement of cocaine seeking using this new mouse model and the in situ hybridization technique. We have demonstrated that cue-elicited reinstatement of cocaine seeking was associated with induction of the IEG in the medial prefrontal cortex (prelimbic and infralimbic) and basolateral amygdala. Priming-induced reinstatement produced a more widespread up-regulation of those genes in forebrain regions including medial prefrontal, orbitofrontal and motor cortex, dorsal striatum and basolateral amygdala. These patterns of IEG expression are in agreement with previous results obtained in rats and thus indicate that the new mouse model of reinstatement is functionally equivalent to rat models. That comparability adds to the usefulness of the mouse model as a tool for addressing neurobiological mechanisms of addiction. Springer-Verlag, 2011 Cocaine nationallicence Drug seeking nationallicence Reinstatement nationallicence Immediate early gene nationallicence Brain activity mapping nationallicence Ziółkowska Barbara Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut Kiełbiński Michał Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut Gieryk Agnieszka Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut Soria Guadalupe Laboratorio de Neurofarmacología, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, C/Dr. Aiguader 88, 08003, Barcelona, Spain aut Maldonado Rafael Laboratorio de Neurofarmacología, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, C/Dr. Aiguader 88, 08003, Barcelona, Spain aut Przewłocki Ryszard Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 877-887 0300-9564 118:6<877 2011 118 702 https://doi.org/10.1007/s00702-011-0583-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0583-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ziółkowska Barbara Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Kiełbiński Michał Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Gieryk Agnieszka Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Soria Guadalupe Laboratorio de Neurofarmacología, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, C/Dr. Aiguader 88, 08003, Barcelona, Spain aut NATIONALLICENCE 700 1- Maldonado Rafael Laboratorio de Neurofarmacología, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, C/Dr. Aiguader 88, 08003, Barcelona, Spain aut NATIONALLICENCE 700 1- Przewłocki Ryszard Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 877-887 0300-9564 118:6<877 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer