caa a22 4500 445376198 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00702-010-0567-4 doi (NATIONALLICENCE)springer-10.1007/s00702-010-0567-4 Association between neuroendocrinological parameters and learning and memory functions in adolescent anorexia nervosa before and after weight recovery [Elektronische Daten] [Katharina Buehren, Kerstin Konrad, Kerstin Schaefer, Juergen Kratzsch, Berak Kahraman-Lanzerath, Christina Lente, Beate Herpertz-Dahlmann] A growing body of evidence indicates that hormones play an important role in learning and memory functions as well as in mood modulation. During the acute stage of anorexia nervosa (AN), weight loss has a significant effect on serum levels of estrogen, thyroid hormones, and cortisol. Furthermore deficits in learning and memory functions are evident in patients with eating disorders during emaciation. Hormonal and neuropsychological alterations at least partly remit during weight restoration. We investigated the association between learning and memory functions as well as mood and neuroendocrinological parameters before and after weight gain in adolescent AN. Twenty-eight female subjects with AN, diagnosed according to DSM-IV, were examined before and after weight recovery. Both investigations took place while the patients were receiving hospital treatment, and the results were compared to a control group consisting of 18 age- and IQ-matched normal-weight female adolescents also tested twice within 4months. Verbal memory and learning were assessed by a German paper-pencil-test (LGT). We performed correlation calculations between neuropsychological functions and depressive symptoms and estrogen, cortisol and free triiodothyronine (fT3) in the plasma at both time points. Compared to normal controls adolescents with AN performed worse in one subtest of the LGT which requires the verbal reproduction of figural material across both time points. Verbal learning was positively correlated with estrogen levels after weight recovery. Depressive symptoms of AN patients significantly decreased during weight rehabilitation and correlated negatively with fT3 at T 1. We did not find a relationship between cortisol levels and neuropsychological functions. We observed subtle memory impairments and depressive symptoms in subjects with adolescent AN associated with starvation-induced estrogen and triiodothyronine deficits, respectively. Normalization of body weight and resuming of menses is needed to restore learning and memory functions as well as to alleviate depressive symptoms. Springer-Verlag, 2010 Learning nationallicence Memory nationallicence Depression nationallicence Anorexia nervosa nationallicence Estrogen nationallicence Triiodothyronine nationallicence Buehren Katharina University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut Konrad Kerstin University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut Schaefer Kerstin University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut Kratzsch Juergen University Hospital Leipzig, Liebigstraße 27, 04103, Leipzig, Germany aut Kahraman-Lanzerath Berak University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut Lente Christina University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut Herpertz-Dahlmann Beate University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 963-968 0300-9564 118:6<963 2011 118 702 https://doi.org/10.1007/s00702-010-0567-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0567-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buehren Katharina University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Konrad Kerstin University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Schaefer Kerstin University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Kratzsch Juergen University Hospital Leipzig, Liebigstraße 27, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Kahraman-Lanzerath Berak University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Lente Christina University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Herpertz-Dahlmann Beate University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 963-968 0300-9564 118:6<963 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer