caa a22 4500 445376201 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00702-011-0585-x doi (NATIONALLICENCE)springer-10.1007/s00702-011-0585-x Involvement of NMDA receptor complex in the anxiolytic-like effects of chlordiazepoxide in mice [Elektronische Daten] [Ewa Poleszak, Katarzyna Socała, Aleksandra Szopa, Andrzej Wróbel, Bernadeta Szewczyk, Regina Kasperek, Eliza Blicharska, Gabriel Nowak, Piotr Wlaź] In the present study, we demonstrated that low, ineffective doses of N-methyl-d-aspartic acid (NMDA) receptor antagonists [competitive NMDA antagonist, CGP 37849, at 0.312mg/kg intraperitoneally (i.p.), antagonist of the glycineB sites, L-701,324, at 2mg/kg i.p., partial agonist of glycineB sites, d-cycloserine, at 2.5mg/kg i.p.] administered jointly with an ineffective dose of the benzodiazepine, chlordiazepoxide (CDP, 2.5mg/kg i.p.), significantly increased the percentage of time spent in the open arms of the elevated plus-maze (index of anxiolytic effect). Furthermore, CDP-induced anxiolytic-like activity (5mg/kg i.p.) was antagonized by NMDA (75mg/kg i.p.) and by an agonist of glycineB sites of the NMDA receptor complex, d-serine [100nmol/mouse intracerebroventricularly (i.c.v.)]. The present study showed a positive interaction between γ-aminobutyric acid (GABA) and glutamate neurotransmission in the anxiolytic-like activity in the elevated plus-maze test in mice and this activity seems to particularly involve the NMDA receptors. The Author(s), 2011 Chlordiazepoxide nationallicence NMDA receptor ligands nationallicence Anxiety nationallicence Elevated plus-maze nationallicence Mice nationallicence Poleszak Ewa Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland aut Socała Katarzyna Department of Animal Physiology, Institute of Biology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland aut Szopa Aleksandra Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland aut Wróbel Andrzej Second Department of Gynecology, Medical University of Lublin, Lublin, Poland aut Szewczyk Bernadeta Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Kasperek Regina Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland aut Blicharska Eliza Department of Analytical Chemistry, Medical University of Lublin, Lublin, Poland aut Nowak Gabriel Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Wlaź Piotr Department of Animal Physiology, Institute of Biology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland aut Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 857-864 0300-9564 118:6<857 2011 118 702 https://doi.org/10.1007/s00702-011-0585-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0585-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poleszak Ewa Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland aut NATIONALLICENCE 700 1- Socała Katarzyna Department of Animal Physiology, Institute of Biology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland aut NATIONALLICENCE 700 1- Szopa Aleksandra Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland aut NATIONALLICENCE 700 1- Wróbel Andrzej Second Department of Gynecology, Medical University of Lublin, Lublin, Poland aut NATIONALLICENCE 700 1- Szewczyk Bernadeta Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Kasperek Regina Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland aut NATIONALLICENCE 700 1- Blicharska Eliza Department of Analytical Chemistry, Medical University of Lublin, Lublin, Poland aut NATIONALLICENCE 700 1- Nowak Gabriel Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Wlaź Piotr Department of Animal Physiology, Institute of Biology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 857-864 0300-9564 118:6<857 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer