caa a22 4500 445376228 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00702-011-0605-x doi (NATIONALLICENCE)springer-10.1007/s00702-011-0605-x Cerebrospinal fluid/plasma quotients of essential and non-essential metals in patients with Alzheimer's disease [Elektronische Daten] [Lars Gerhardsson, Thomas Lundh, Elisabet Londos, Lennart Minthon] In this study, the quotients (Q) between metal concentrations in cerebrospinal fluid (CSF) and plasma were studied in subjects with Alzheimer's disease (AD) and referents to investigate if the leakage through the blood-CSF barrier (BCB) increased with increased duration and severity of the disease. Concentrations of 18 metals (Mg, Ca, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg, and Pb) were determined by ICP-MS in plasma and cerebrospinal fluid in 264 patients with AD, and in 54 healthy referents. The quotients Q Mn, Q Rb, Q Sb, Q Pb and Q Hg were significantly lower (p≤0.003) and Q Co significantly higher (p≤0.001) in subjects with AD as compared with the controls. Subjects in a subgroup with more severe AD, showed the same pattern. The metal leakage into CSF did not increase with increased duration and/or severity of the disease. The permeability of BCB varied considerably between the studied metals with low median quotients (Q≤0.02) for Cd, Cu, Sb, Se and Zn and higher median quotients for Ca (Q~0.5) and Mg (Q~1.3), probably partly depending on differences in size and lipophilicity of metal-carrier complexes and specific carrier mechanisms. Springer-Verlag, 2011 Alzheimer's disease nationallicence Blood-CSF barrier nationallicence Metals nationallicence Blood nationallicence Cerebrospinal fluid nationallicence Gerhardsson Lars Department of Occupational and Environmental Medicine, Sahlgrenska Academy and University Hospital, Box 414, SE-405 30, Gothenburg, Sweden aut Lundh Thomas Department of Occupational and Environmental Medicine, University Hospital, SE-221 85, Lund, Sweden aut Londos Elisabet Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, SE-205 02, Malmo, Sweden aut Minthon Lennart Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, SE-205 02, Malmo, Sweden aut Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 957-962 0300-9564 118:6<957 2011 118 702 https://doi.org/10.1007/s00702-011-0605-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0605-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gerhardsson Lars Department of Occupational and Environmental Medicine, Sahlgrenska Academy and University Hospital, Box 414, SE-405 30, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Lundh Thomas Department of Occupational and Environmental Medicine, University Hospital, SE-221 85, Lund, Sweden aut NATIONALLICENCE 700 1- Londos Elisabet Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, SE-205 02, Malmo, Sweden aut NATIONALLICENCE 700 1- Minthon Lennart Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, SE-205 02, Malmo, Sweden aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 957-962 0300-9564 118:6<957 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer