caa a22 4500 445376244 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00702-011-0587-8 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0587-8 Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T) [Elektronische Daten] [Shoko Koshiba, Hirofumi Tokuoka, Teruo Yokoyama, Emiko Horiuchi, Hiroshi Ichinose, Kazuko Hasegawa] PARK8 is the most common form of familial Parkinson's disease (PD). We measured biopterin and monoamine metabolite levels in the cerebrospinal fluids of 7 PARK8 patients (I2020T mutation in leucine-rich repeat kinase 2), 2 asymptomatic mutation carriers, and 21 sporadic PD patients. The biopterin levels in PARK8 patients were significantly higher than those in sporadic PD patients, although the symptoms were comparable in both groups, suggesting that PARK8 patients exhibit parkinsonian symptoms with higher biopterin levels than sporadic PD patients. Springer-Verlag, 2011 Parkinson's disease nationallicence PARK8 nationallicence Biopterin nationallicence Cerebrospinal fluid nationallicence Dopamine nationallicence Leucine-rich repeat kinase 2 nationallicence Koshiba Shoko Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, 226-8501, Yokohama, Japan aut Tokuoka Hirofumi Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, 226-8501, Yokohama, Japan aut Yokoyama Teruo Division of Neurology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, 252-0392, Sagamihara, Japan aut Horiuchi Emiko Division of Neurology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, 252-0392, Sagamihara, Japan aut Ichinose Hiroshi Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, 226-8501, Yokohama, Japan aut Hasegawa Kazuko Division of Neurology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, 252-0392, Sagamihara, Japan aut Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 899-903 0300-9564 118:6<899 2011 118 702 https://doi.org/10.1007/s00702-011-0587-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0587-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koshiba Shoko Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, 226-8501, Yokohama, Japan aut NATIONALLICENCE 700 1- Tokuoka Hirofumi Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, 226-8501, Yokohama, Japan aut NATIONALLICENCE 700 1- Yokoyama Teruo Division of Neurology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, 252-0392, Sagamihara, Japan aut NATIONALLICENCE 700 1- Horiuchi Emiko Division of Neurology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, 252-0392, Sagamihara, Japan aut NATIONALLICENCE 700 1- Ichinose Hiroshi Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, 226-8501, Yokohama, Japan aut NATIONALLICENCE 700 1- Hasegawa Kazuko Division of Neurology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, 252-0392, Sagamihara, Japan aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/6(2011-06-01), 899-903 0300-9564 118:6<899 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer