caa a22 4500 445376333 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00702-011-0612-y doi (NATIONALLICENCE)springer-10.1007/s00702-011-0612-y APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population [Elektronische Daten] [Chikako Kiyohara, Yoshihiro Miyake, Midori Koyanagi, Takahiro Fujimoto, Senji Shirasawa, Keiko Tanaka, Wakaba Fukushima, Satoshi Sasaki, Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oeda, Takami Miki, Nobutoshi Kawamura, Nobutaka Sakae, Hidenao Fukuyama, Yoshio Hirota, Masaki Nagai] Apolipoprotein E (APOE) is associated with increased oxidative stress, which is caused by reactive oxygen species (ROS). Enhanced cytochrome P450 2E1 (CYP2E1) activity may also increase formation of neurotoxins such as ROS. As Parkinson's disease (PD) is a neurodegenerative disorder, both the APOE and CYP2E1 genes that are involved in neurodegeneration by oxidative stress may be associated with PD risk. We investigated the relationship of the APOE and CYP2E1 rs2864987 polymorphisms and PD risk with special attention to the interaction with alcohol consumption among 238 patients with PD and 296 controls in a Japanese population. The frequencies of the ɛ2, ɛ3, and ɛ4 alleles of the APOE polymorphism among controls were 3.72, 86.7, and 9.63%, respectively. As compared with the APOE ε3/ε3 genotype, the 2/ε4 genotype was associated with an increased risk of PD (adjusted odds ratio (OR) = 9.50, 95% (confidence interval) CI = 1.12-80.6). The presence of the ε3 allele was associated with a decreased risk of PD. Meanwhile, CYP2E1 rs2864987 was not associated with PD risk. Although CYP2E1 is involved in the metabolism of alcohol, there was no evidence of interaction between alcohol consumption and CYP2E1 rs2864987. Our results suggested that the APOE polymorphism might play an important role in PD susceptibility in our Japanese population. Future studies involving larger control and case populations and better alcohol consumption histories will undoubtedly lead to a more thorough understanding of the role of polymorphisms of genes related to the generation of ROS in PD development. Springer-Verlag, 2011 Apolipoprotein E nationallicence Cytochrome P450 2E1 nationallicence Interaction nationallicence Parkinson's disease nationallicence Case-control study nationallicence Japanese population nationallicence Kiyohara Chikako Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Miyake Yoshihiro Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Koyanagi Midori Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Fujimoto Takahiro Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Shirasawa Senji Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Tanaka Keiko Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Fukushima Wakaba Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan aut Sasaki Satoshi Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan aut Tsuboi Yoshio Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Yamada Tatsuo Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Oeda Tomoko Clinical Research Institute and Department of Neurology, Utano National Hospital, Kyoto, Japan aut Miki Takami Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan aut Kawamura Nobutoshi Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Sakae Nobutaka Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Fukuyama Hidenao Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan aut Hirota Yoshio Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan aut Nagai Masaki Department of Public Health, Saitama Medical University Faculty of Medicine, Saitama, Japan aut Journal of Neural Transmission Springer Vienna 118/9(2011-09-01), 1335-1344 0300-9564 118:9<1335 2011 118 702 https://doi.org/10.1007/s00702-011-0612-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0612-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kiyohara Chikako Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Miyake Yoshihiro Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Koyanagi Midori Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Fujimoto Takahiro Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Shirasawa Senji Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tanaka Keiko Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Fukushima Wakaba Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Sasaki Satoshi Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsuboi Yoshio Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yamada Tatsuo Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Oeda Tomoko Clinical Research Institute and Department of Neurology, Utano National Hospital, Kyoto, Japan aut NATIONALLICENCE 700 1- Miki Takami Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Kawamura Nobutoshi Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sakae Nobutaka Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Fukuyama Hidenao Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Hirota Yoshio Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Nagai Masaki Department of Public Health, Saitama Medical University Faculty of Medicine, Saitama, Japan aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/9(2011-09-01), 1335-1344 0300-9564 118:9<1335 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence 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