caa a22 4500 44537635X CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00702-011-0629-2 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0629-2 Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury [Elektronische Daten] [Tatsuki Itoh, Motohiro Imano, Shozo Nishida, Masahiro Tsubaki, Shigeo Hashimoto, Akihiko Ito, Takao Satou] Exercise is reported to inhibit neuronal apoptotic cell death in the hippocampus and improve learning and memory. However, the effect of exercise on inhibition of neuronal apoptosis surrounding the area of damage after traumatic brain injury (TBI) and the improvement of cerebral dysfunction following TBI are unknown. Here, we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device were randomly divided into two groups: (1) non-exercise group and (2) exercise group. The exercise group ran on a treadmill for 30min/day at 22m/min for seven consecutive days. Immunohistochemical and behavioral studies were performed following TBI. The number of single-stranded DNA (ssDNA)-positive cells around the damaged area early after TBI was significantly reduced in the exercise group compared with the non-exercise group (P<0.05). Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, a few ssDNA-positive cells co-localized with neurons. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group compared with the non-exercise group (P<0.05). These results indicate that exercise following TBI inhibits neuronal degeneration and apoptotic cell death around the damaged area, which results in improvement of cerebral dysfunction. In summary, treadmill running improved cerebral dysfunction following TBI, indicating its potential as an effective clinical therapy. Therefore, exercise therapy (rehabilitation) in the early phase following TBI is important for recuperation from cerebral dysfunction. Springer-Verlag, 2011 Cerebral dysfunction nationallicence Neuroprotection nationallicence Apoptotic cell death nationallicence Neuronal degeneration nationallicence Itoh Tatsuki Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, 589-8511, Osakasayama, Osaka, Japan aut Imano Motohiro Department of Surgery, Kinki University School of Medicine, Osakasayama, Osaka, Japan aut Nishida Shozo Kinki University School of Pharmaceutical Sciences, Osaka, Japan aut Tsubaki Masahiro Kinki University School of Pharmaceutical Sciences, Osaka, Japan aut Hashimoto Shigeo Division of Pathology, PL Hospital, Osaka, Japan aut Ito Akihiko Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, 589-8511, Osakasayama, Osaka, Japan aut Satou Takao Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, 589-8511, Osakasayama, Osaka, Japan aut Journal of Neural Transmission Springer Vienna 118/9(2011-09-01), 1263-1272 0300-9564 118:9<1263 2011 118 702 https://doi.org/10.1007/s00702-011-0629-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0629-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Tatsuki Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, 589-8511, Osakasayama, Osaka, Japan aut NATIONALLICENCE 700 1- Imano Motohiro Department of Surgery, Kinki University School of Medicine, Osakasayama, Osaka, Japan aut NATIONALLICENCE 700 1- Nishida Shozo Kinki University School of Pharmaceutical Sciences, Osaka, Japan aut NATIONALLICENCE 700 1- Tsubaki Masahiro Kinki University School of Pharmaceutical Sciences, Osaka, Japan aut NATIONALLICENCE 700 1- Hashimoto Shigeo Division of Pathology, PL Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Ito Akihiko Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, 589-8511, Osakasayama, Osaka, Japan aut NATIONALLICENCE 700 1- Satou Takao Department of Pathology, Kinki University School of Medicine, 377-2 Ohno-higashi, 589-8511, Osakasayama, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/9(2011-09-01), 1263-1272 0300-9564 118:9<1263 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer