caa a22 4500 445376384 CHVBK 20180317143003.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00702-011-0650-5 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0650-5 Cognitive function and cholinergic transmission in patients with subcortical vascular dementia and microbleeds: a TMS study [Elektronische Daten] [Raffaele Nardone, Pierpaolo De Blasi, Martin Seidl, Yvonne Höller, Francesca Caleri, Frediano Tezzon, Gunther Ladurner, Stefan Golaszewski, Eugen Trinka] There has been little investigation on the association between cognitive impairment and the microbleeds (MBs) frequently seen in subcortical vascular dementia (SVaD). One possible mechanism of cognitive decline in individuals with SVaD could be disruption of cholinergic fibers by vascular lesions. Central cholinergic circuits in human brain can be tested non-invasively by means of a transcranial magnetic stimulation (TMS) protocol named short latency afferent inhibition (SAI) of motor cortex. In the present study, we used this test in SvaD patients with and without MBs. SAI was evaluated in 13 SVaD patients with MBs (MB-positive group) and the data were compared with those from a group of 15 SVaD patients without MBs (MB-negative group) and with those from 20 healthy subjects. Moreover, we studied covariation of individual SAI values with the Mini-Mental State Examination (MMSE) total score and subscores. SAI was significantly reduced in the MB-positive group when compared with the MB-negative group and the control subjects. Total MMSE score, "attention and calculation” and "orientation” subscores were significantly lower in the MB-positive group than in the MB-negative group; SAI showed a positive correlation with total MMSE score. Adjustment for age, gender, education, presence of lacunae, severe white matter hyperintensities or severe periventricular hyperintensities did not affect these findings. This study provides novel physiological evidence that MBs have an impact on central cholinergic function that is independent of the extent of associated white matter changes and ischaemic stroke. This finding shows that TMS have potential diagnostic and therapeutic implications. TMS studies may help in evaluating the causes of cognitive impairment in cerebrovascular diseases. Springer-Verlag, 2011 Microbleeds nationallicence Subcortical vascular dementia nationallicence Transcranial magnetic stimulation nationallicence Short latency afferent inhibition nationallicence Mini-Mental State Examination nationallicence Nardone Raffaele Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut De Blasi Pierpaolo Department of Economics, Collegio Carlo Alberto, University of Turin, Turin, Italy aut Seidl Martin Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut Höller Yvonne Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria aut Caleri Francesca Department of Neurology, "F. Tappeiner” Hospital, Via Rossini, 5, 39012, Meran/o (BZ), Italy aut Tezzon Frediano Department of Neurology, "F. Tappeiner” Hospital, Via Rossini, 5, 39012, Meran/o (BZ), Italy aut Ladurner Gunther Neuroscience Institute, Christian Doppler Clinic, Salzburg, Austria aut Golaszewski Stefan Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut Trinka Eugen Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut Journal of Neural Transmission Springer Vienna 118/9(2011-09-01), 1349-1358 0300-9564 118:9<1349 2011 118 702 https://doi.org/10.1007/s00702-011-0650-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0650-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nardone Raffaele Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut NATIONALLICENCE 700 1- De Blasi Pierpaolo Department of Economics, Collegio Carlo Alberto, University of Turin, Turin, Italy aut NATIONALLICENCE 700 1- Seidl Martin Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut NATIONALLICENCE 700 1- Höller Yvonne Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria aut NATIONALLICENCE 700 1- Caleri Francesca Department of Neurology, "F. Tappeiner” Hospital, Via Rossini, 5, 39012, Meran/o (BZ), Italy aut NATIONALLICENCE 700 1- Tezzon Frediano Department of Neurology, "F. Tappeiner” Hospital, Via Rossini, 5, 39012, Meran/o (BZ), Italy aut NATIONALLICENCE 700 1- Ladurner Gunther Neuroscience Institute, Christian Doppler Clinic, Salzburg, Austria aut NATIONALLICENCE 700 1- Golaszewski Stefan Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut NATIONALLICENCE 700 1- Trinka Eugen Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/9(2011-09-01), 1349-1358 0300-9564 118:9<1349 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer