caa a22 4500 445376414 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00702-010-0561-x doi (NATIONALLICENCE)springer-10.1007/s00702-010-0561-x Berry Mark Department of Chemistry, Brandon University, R7A 6A9, Brandon, MB, Canada aut The effects of pargyline and 2-phenylethylamine on D1-like dopamine receptor binding [Elektronische Daten] [Mark Berry] 2-Phenylethylamine (PE) potentiates neuronal responses to dopamine by an unknown post-synaptic mechanism. Here, whether PE modifies D1-like receptor binding was examined. An unexpected effect of the monoamine oxidase inhibitor pargyline was observed, which did not involve competition for ligand binding. PE did not affect ligand binding in the presence or absence of pargyline. It is concluded that the effect of pargyline does not involve elevation of endogenous PE, and PE effects on dopaminergic neurotransmission are not due to altered D1-like receptor binding. Springer-Verlag, 2010 D1 dopamine receptors nationallicence Trace amines nationallicence Monoamine oxidase inhibitor nationallicence 2-Phenylethylamine nationallicence Pargyline nationallicence Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1115-1118 0300-9564 118:7<1115 2011 118 702 https://doi.org/10.1007/s00702-010-0561-x text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0561-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Berry Mark Department of Chemistry, Brandon University, R7A 6A9, Brandon, MB, Canada aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1115-1118 0300-9564 118:7<1115 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer