caa a22 4500 445376473 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00702-011-0595-8 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0595-8 Preliminary studies of the effects of vascular adhesion protein-1 inhibitors on experimental corneal neovascularization [Elektronische Daten] [Anna Énzsöly, Petra Dunkel, Zsuzsa Récsán, Hajnalka Győrffy, Jeanette Tóth, Gábor Marics, Zoltán Bori, Miklós Tóth, Romána Zelkó, Maria Paolo, Péter Mátyus, János Németh] Vascular adhesion protein-1 (VAP-1) controls the adhesion of lymphocytes to endothelial cells and is upregulated at sites of inflammation. Moreover, it expresses amine oxidase activity, due to the sequence identity with semicarbazide-sensitive amine oxidase. Recent studies indicate a significant role for VAP-1 in neovascularization, besides its contribution to inflammation. Pathological blood vessel development in severe ocular diseases (such as diabetes, age-related macula degeneration, trauma and infections) might lead to decreased visual acuity and finally to blindness, yet there is no clear consensus as to its appropriate treatment. In the present case study, the effects of two VAP-1 inhibitors on experimentally induced corneal neovascularization in rabbits were compared with the effects of a known inhibitor of angiogenesis, bevacizumab, an anti-vascular endothelial growth factor antibody. In accordance with recent literature data, the results of the preliminary study reported here indicate that the administration of VAP-1 inhibitors is a potentially valuable therapeutic option in the treatment of corneal neovascularization. Springer-Verlag, 2011 Semicarbazide-sensitive amine oxidase (SSAO) nationallicence Vascular adhesion protein-1 (VAP-1) nationallicence Corneal neovascularization nationallicence Alkali burn model nationallicence Énzsöly Anna Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut Dunkel Petra Department of Organic Chemistry, Semmelweis University, Hőgyes Endre u. 7, 1092, Budapest, Hungary aut Récsán Zsuzsa Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut Győrffy Hajnalka Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut Tóth Jeanette Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut Marics Gábor Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut Bori Zoltán Department of Health Sciences and Sport Medicine, Semmelweis University, Alkotás u. 44, 1123, Budapest, Hungary aut Tóth Miklós Department of Health Sciences and Sport Medicine, Semmelweis University, Alkotás u. 44, 1123, Budapest, Hungary aut Zelkó Romána University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. u. 7-9, 1092, Budapest, Hungary aut Paolo Maria Department of Biological Chemistry, University of Padova, Via G. Colombo, 3, 35131, Padua, Italy aut Mátyus Péter Department of Organic Chemistry, Semmelweis University, Hőgyes Endre u. 7, 1092, Budapest, Hungary aut Németh János Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1065-1069 0300-9564 118:7<1065 2011 118 702 https://doi.org/10.1007/s00702-011-0595-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0595-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Énzsöly Anna Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Dunkel Petra Department of Organic Chemistry, Semmelweis University, Hőgyes Endre u. 7, 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Récsán Zsuzsa Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Győrffy Hajnalka Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Tóth Jeanette Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Marics Gábor Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Bori Zoltán Department of Health Sciences and Sport Medicine, Semmelweis University, Alkotás u. 44, 1123, Budapest, Hungary aut NATIONALLICENCE 700 1- Tóth Miklós Department of Health Sciences and Sport Medicine, Semmelweis University, Alkotás u. 44, 1123, Budapest, Hungary aut NATIONALLICENCE 700 1- Zelkó Romána University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. u. 7-9, 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Paolo Maria Department of Biological Chemistry, University of Padova, Via G. Colombo, 3, 35131, Padua, Italy aut NATIONALLICENCE 700 1- Mátyus Péter Department of Organic Chemistry, Semmelweis University, Hőgyes Endre u. 7, 1092, Budapest, Hungary aut NATIONALLICENCE 700 1- Németh János Department of Ophthalmology, Semmelweis University, Mária u. 39, 1085, Budapest, Hungary aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1065-1069 0300-9564 118:7<1065 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer