caa a22 4500 445376503 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00702-011-0647-0 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0647-0 Hepatic consequences of vascular adhesion protein-1 expression [Elektronische Daten] [Chris Weston, David Adams] The liver is constantly exposed to antigens present in the blood and to particulate antigens delivered from the gut. To maintain effective levels of immune surveillance and yet tolerate food antigens, the hepatic environment has become highly specialised. A low flow environment exists within the hepatic sinusoids that not only facilitates the exchange of toxins and nutrients within the liver parenchyma, but also provides an ideal niche for the recruitment of leukocytes. One such adhesion molecule involved in this process, the vascular adhesion protein-1 (VAP-1), is unusual in the context of the leukocyte adhesion cascade in that it is both an adhesion molecule and a primary amine oxidase. In this review, we examine the biological functions of VAP-1 and examine what role this molecule might play in the establishment and progression of chronic liver disease. Springer-Verlag, 2011 Vascular adhesion protein-1 nationallicence SSAO nationallicence Liver nationallicence Hepatic nationallicence Leukocyte recruitment nationallicence Primary amine oxidase nationallicence HCC : Hepatocellular carcinoma nationallicence HCV : Hepatitis C virus nationallicence HEV : High endothelial venule nationallicence LSEC : Liver sinusoidal endothelial cells nationallicence LOX : Lysyl oxidase nationallicence MAdCAM-1 : Mucosal addressin cell adhesion molecule-1 nationallicence MAO : Monoamine oxidase nationallicence NAFLD : Non-alcoholic fatty liver disease nationallicence NASH : Non-alcoholic steatohepatitis nationallicence PBC : Primary biliary cirrhosis nationallicence PSC : Primary sclerosing cholangitis nationallicence SSAO : Semicarbazide sensitive amine oxidase nationallicence VAP-1 : Vascular adhesion protein-1 nationallicence Weston Chris Centre for Liver Research and NIHR Biomedical Research Unit, 5th Floor, Institute of Biomedical Research, MRC Centre for Immune Regulation, College of Medicine and Dentistry, University of Birmingham, B15 2TT, Birmingham, Edgbaston, UK aut Adams David Centre for Liver Research and NIHR Biomedical Research Unit, 5th Floor, Institute of Biomedical Research, MRC Centre for Immune Regulation, College of Medicine and Dentistry, University of Birmingham, B15 2TT, Birmingham, Edgbaston, UK aut Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1055-1064 0300-9564 118:7<1055 2011 118 702 https://doi.org/10.1007/s00702-011-0647-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0647-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weston Chris Centre for Liver Research and NIHR Biomedical Research Unit, 5th Floor, Institute of Biomedical Research, MRC Centre for Immune Regulation, College of Medicine and Dentistry, University of Birmingham, B15 2TT, Birmingham, Edgbaston, UK aut NATIONALLICENCE 700 1- Adams David Centre for Liver Research and NIHR Biomedical Research Unit, 5th Floor, Institute of Biomedical Research, MRC Centre for Immune Regulation, College of Medicine and Dentistry, University of Birmingham, B15 2TT, Birmingham, Edgbaston, UK aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1055-1064 0300-9564 118:7<1055 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer