caa a22 4500 445376511 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00702-011-0655-0 doi (NATIONALLICENCE)springer-10.1007/s00702-011-0655-0 Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells [Elektronische Daten] [Zhi-qiang Wang, Kevin Chen, Qi-long Ying, Ping Li, Jean Shih] Monoamine oxidase (MAO) A is the major metabolizing enzyme of serotonin (5-hydroxytryptamine, 5-HT) which regulates early brain development. In this study, wild-type (WT) and MAO Aneo embryonic stem (ES) cell lines were established from the inner cell mass of murine blastocysts and their characteristics during ES and differentiating stages were studied. Our results show that the differentiation to neural cells in MAO Aneo ES cells was reduced compared to WT, suggesting MAO A played a regulatory role in stem cells neural differentiation. Springer-Verlag, 2011 Embryonic stem cells nationallicence Neural differentiation nationallicence Neurogenesis nationallicence Monoamine oxidase (MAO) A nationallicence Wang Zhi-qiang Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA aut Chen Kevin Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA aut Ying Qi-long Department of Cell and Neurobiology, Center for Stem Cell and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut Li Ping Department of Cell and Neurobiology, Center for Stem Cell and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut Shih Jean Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA aut Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 997-1001 0300-9564 118:7<997 2011 118 702 https://doi.org/10.1007/s00702-011-0655-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-011-0655-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Zhi-qiang Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Chen Kevin Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Ying Qi-long Department of Cell and Neurobiology, Center for Stem Cell and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Li Ping Department of Cell and Neurobiology, Center for Stem Cell and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Shih Jean Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 997-1001 0300-9564 118:7<997 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer