caa a22 4500 445376554 CHVBK 20180317143004.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00702-010-0537-x doi (NATIONALLICENCE)springer-10.1007/s00702-010-0537-x Dietary inhibitors of monoamine oxidase A [Elektronische Daten] [Sarah Dixon Clarke, Rona Ramsay] Inhibition of monoamine oxidase is one way to treat depression and anxiety. The information now available on the pharmacokinetics of flavonoids and of the components of tobacco prompted an exploration of whether a healthy diet (with or without smoking) provides active compounds in amounts sufficient to partially inhibit monoamine oxidase. A literature search was used to identify dietary monoamine oxidase inhibitors, the levels of these compounds in foods, the pharmacokinetics of the absorption and distribution, and tissue levels observed. An estimated daily intake and the expected tissue concentrations were compared with the measured efficacies of the compounds as inhibitors of monoamine oxidases. Norharman, harman and quercetin dietary presence, pharmacokinetics, and tissue levels were consistent with significant levels reaching neuronal monoamine oxidase from the diet or smoking; 1,2,3,4-tetrahydroisoquinoline, eugenol, 1-piperoylpiperidine, and coumarin were not. Quercetin was equipotent with norharman as a monoamine oxidase A inhibitor and its metabolite, isorhamnetin, also inhibits. Total quercetin was the highest of the compounds in the sample diet. Although bioavailability was variable depending on the source, a healthy diet contains amounts of quercetin that might give sufficient amounts in brain to induce, by monoamine oxidase A inhibition, a small decrease in neurotransmitter breakdown. Springer-Verlag, 2010 Antidepressant nationallicence Harman nationallicence Monoamine oxidase A nationallicence Norharman nationallicence Quercetin nationallicence BBB : Blood-brain barrier nationallicence FST : Forced swim test nationallicence MAO : Monoamine oxidase nationallicence TIQ : 1,2,3,4-Tetrahydroisoquinoline nationallicence Dixon Clarke Sarah Biomedical Sciences Research Complex, University of St Andrews, North Haugh, KY16 9ST, St Andrews, Fife, UK aut Ramsay Rona Biomedical Sciences Research Complex, University of St Andrews, North Haugh, KY16 9ST, St Andrews, Fife, UK aut Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1031-1041 0300-9564 118:7<1031 2011 118 702 https://doi.org/10.1007/s00702-010-0537-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00702-010-0537-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dixon Clarke Sarah Biomedical Sciences Research Complex, University of St Andrews, North Haugh, KY16 9ST, St Andrews, Fife, UK aut NATIONALLICENCE 700 1- Ramsay Rona Biomedical Sciences Research Complex, University of St Andrews, North Haugh, KY16 9ST, St Andrews, Fife, UK aut NATIONALLICENCE 773 0- Journal of Neural Transmission Springer Vienna 118/7(2011-07-01), 1031-1041 0300-9564 118:7<1031 2011 118 702 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer